Structural and CBCT analysis of mandibular canal microvessels expressing neurotransmitters in human cadavers.

IF 1.2 4区医学 Q3 ANATOMY & MORPHOLOGY

Surgical and Radiologic Anatomy Pub Date : 2023-08-01 DOI:10.1007/s00276-023-03184-x

Masachika Takiguchi, Iwao Sato, Yoko Ueda, Shinichi Kawata, Yutaro Natsuyama, Tomiko Yakura, Zhong-Lian Li, Masahiro Itoh

{"title":"Structural and CBCT analysis of mandibular canal microvessels expressing neurotransmitters in human cadavers.","authors":"Masachika Takiguchi, Iwao Sato, Yoko Ueda, Shinichi Kawata, Yutaro Natsuyama, Tomiko Yakura, Zhong-Lian Li, Masahiro Itoh","doi":"10.1007/s00276-023-03184-x","DOIUrl":null,"url":null,"abstract":"Purpose: This study focused on the detailed structure of microvessels of the neurotransmitter-positive vasa nervorum of the inferior alveolar nerve, vein, and artery in the mandibular canal (MC) to obtain information for improved safety in dental treatments. We also observed the detailed structure of the MC from the mental foramen to the mandibular foramen using cone-beam computed tomography (CBCT).Methods: In this study, mandibles from 45 sides of 23 human cadavers aged 76-104 years were examined by microscopy, immunohistochemistry, and CBCT analysis. These data were further evaluated by principal component analysis (PCA).Results: The microvessels of the vasa nervorum with calcitonin gene-related peptide- and neuropeptide Y-positive reactions were classified into 5 types: large (4.19%, 28/667); irregular large (7.35%, 49/667), numerous intermediate (29.23%, 195/667), irregular intermediate (29.23%, 195/667), and scattered fine (30.0%, 200/667) microvessels. The MC showed various structures from the 3rd molar to the premolars and was also classified into three types, including complete (57.0%, 228/400), partial (33.8%, 135/400), and unclear (9.2%, 37/400), from the mandibular foramen to the mental foramen. PCA results revealed that developed capillaries were mainly localized in the molar region.Conclusions: Fine microvessels of the vasa nervorum expressing neurotransmitters are present from the molar to premolar region, which is key information for mandibular dental treatments. The different microvessel structures also indicate differences in specific characteristics between dentulous and edentulous cadavers regarding oral surgical and implant treatments.","PeriodicalId":49296,"journal":{"name":"Surgical and Radiologic Anatomy","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Surgical and Radiologic Anatomy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00276-023-03184-x","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ANATOMY & MORPHOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study focused on the detailed structure of microvessels of the neurotransmitter-positive vasa nervorum of the inferior alveolar nerve, vein, and artery in the mandibular canal (MC) to obtain information for improved safety in dental treatments. We also observed the detailed structure of the MC from the mental foramen to the mandibular foramen using cone-beam computed tomography (CBCT).

Methods: In this study, mandibles from 45 sides of 23 human cadavers aged 76-104 years were examined by microscopy, immunohistochemistry, and CBCT analysis. These data were further evaluated by principal component analysis (PCA).

Results: The microvessels of the vasa nervorum with calcitonin gene-related peptide- and neuropeptide Y-positive reactions were classified into 5 types: large (4.19%, 28/667); irregular large (7.35%, 49/667), numerous intermediate (29.23%, 195/667), irregular intermediate (29.23%, 195/667), and scattered fine (30.0%, 200/667) microvessels. The MC showed various structures from the 3rd molar to the premolars and was also classified into three types, including complete (57.0%, 228/400), partial (33.8%, 135/400), and unclear (9.2%, 37/400), from the mandibular foramen to the mental foramen. PCA results revealed that developed capillaries were mainly localized in the molar region.

Conclusions: Fine microvessels of the vasa nervorum expressing neurotransmitters are present from the molar to premolar region, which is key information for mandibular dental treatments. The different microvessel structures also indicate differences in specific characteristics between dentulous and edentulous cadavers regarding oral surgical and implant treatments.

查看原文本刊更多论文

人尸体中表达神经递质的下颌管微血管的结构和CBCT分析。

目的:研究下颌管(MC)下牙槽神经、静脉、动脉的神经递质阳性血管神经束微血管的详细结构，为提高牙科治疗的安全性提供信息。我们还使用锥束计算机断层扫描(CBCT)观察了从颏孔到下颌孔的MC的详细结构。方法:对23具76 ~ 104岁人尸体的45侧下颌骨进行了显微镜、免疫组织化学和CBCT分析。用主成分分析(PCA)进一步评价这些数据。结果:神经血管微血管降钙素基因相关肽阳性、神经肽y阳性反应分为5类:大型(4.19%，28/667);不规则的大血管(7.35%，49/667)，大量的中间血管(29.23%，195/667)，不规则的中间血管(29.23%，195/667)，分散的细血管(30.0%，200/667)。从第3磨牙到前磨牙，MC结构多样，从下颌孔到颏孔，MC分为完整型(57.0%，228/400)、部分型(33.8%，135/400)和不清晰型(9.2%，37/400)。PCA结果显示发达的毛细血管主要集中在磨牙区。结论:下颌磨牙区至前磨牙区存在表达神经递质的神经血管微血管，这是下颌牙病治疗的关键信息。不同的微血管结构也表明有牙和无牙尸体在口腔手术和种植治疗方面的具体特征存在差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Surgical and Radiologic Anatomy ANATOMY & MORPHOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

CiteScore

2.70

自引率

14.30%

发文量

183

审稿时长

4-8 weeks

期刊介绍： Anatomy is a morphological science which cannot fail to interest the clinician. The practical application of anatomical research to clinical problems necessitates special adaptation and selectivity in choosing from numerous international works. Although there is a tendency to believe that meaningful advances in anatomy are unlikely, constant revision is necessary. Surgical and Radiologic Anatomy, the first international journal of Clinical anatomy has been created in this spirit. Its goal is to serve clinicians, regardless of speciality-physicians, surgeons, radiologists or other specialists-as an indispensable aid with which they can improve their knowledge of anatomy. Each issue includes: Original papers, review articles, articles on the anatomical bases of medical, surgical and radiological techniques, articles of normal radiologic anatomy, brief reviews of anatomical publications of clinical interest. Particular attention is given to high quality illustrations, which are indispensable for a better understanding of anatomical problems. Surgical and Radiologic Anatomy is a journal written by anatomists for clinicians with a special interest in anatomy.