Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases

IF 6.9 3区医学 Q1 CHEMISTRY, MEDICINAL

Archives of Pharmacal Research Pub Date : 2023-06-24 DOI:10.1007/s12272-023-01452-3

Jin Kyung Seok, Minhyuk Kim, Han Chang Kang, Yong-Yeon Cho, Hye Suk Lee, Joo Young Lee

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引用次数: 3

Abstract

Cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) synthase (cGAS) is a DNA sensor that elicits a robust type I interferon response by recognizing ubiquitous danger-associated molecules. The cGAS/stimulator of interferon genes (cGAS/STING) is activated by endogenous DNA, including DNA released from mitochondria and extranuclear chromatin, as well as exogenous DNA derived from pathogenic microorganisms. cGAS/STING is positioned as a key axis of autoimmunity, the inflammatory response, and cancer progression, suggesting that the cGAS/STING signaling pathway represents an efficient therapeutic target. Based on the accumulated evidence, we present insights into the prevention and treatment of cGAS/STING-related chronic immune and inflammatory diseases. This review presents the current state of clinical and nonclinical development of modulators targeting cGAS/STING, providing useful information on the design of therapeutic strategies.

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超越DNA传感:扩大cGAS/STING在免疫和疾病中的作用

环鸟苷单磷酸腺苷(cGAMP)合成酶(cGAS)是一种DNA传感器，通过识别无处不在的危险相关分子，引发强大的I型干扰素反应。干扰素基因的cGAS/刺激因子(cGAS/STING)被内源性DNA激活，包括线粒体和核外染色质释放的DNA，以及来自病原微生物的外源性DNA。cGAS/STING被定位为自身免疫、炎症反应和癌症进展的关键轴，这表明cGAS/STING信号通路是一个有效的治疗靶点。基于积累的证据，我们对cGAS/ sting相关慢性免疫和炎症疾病的预防和治疗提出了见解。本文综述了靶向cGAS/STING的调节剂的临床和非临床发展现状，为治疗策略的设计提供有用的信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Archives of Pharmacal Research 医学-药学

CiteScore

13.40

自引率

9.00%

发文量

审稿时长

3.3 months

期刊介绍： Archives of Pharmacal Research is the official journal of the Pharmaceutical Society of Korea and has been published since 1976. Archives of Pharmacal Research is an interdisciplinary journal devoted to the publication of original scientific research papers and reviews in the fields of drug discovery, drug development, and drug actions with a view to providing fundamental and novel information on drugs and drug candidates.