Pharmacological Attributes of Fenugreek with Special Reference to Alzheimer's Disease.

IF 1.8 4区 医学 Q3 CLINICAL NEUROLOGY
Himanshi Varshney, Yasir Hasan Siddique
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引用次数: 0

Abstract

Background: An annual plant, Fenugreek (Trigonellafoenum-graecum L.) has well-known health care benefits in Ayurvedic and Chinese medicine. Its leaves and seeds have alkaloids, amino acids, caumarins, flavonoids, saponins, and other bioactive components. Various pharmacological properties such as antioxidants, hypoglycemic, and hypolipidemic have been attributed to fenugreek. Trigonelline, diosgenin, and 4- hydroxyisoleucine have shown neuroprotection against Alzheimer's disease, and the extract have also been reported to act as an anti-depressant, anti-anxiety, and also regulate cognitive functions. This review highlights various studies carried out on animals as well as on humans for the protective effect against Alzheimer's disease.

Methods: The data presented in this review is taken from popular search engines, viz, Google Scholar, PubMed, and Scopus. This review highlights the studies and clinical trials performed to show the protective effect of Fenugreek on neurodegenerative diseases with special reference to AD from 2005 to 2023.

Results: Fenugreek improves cognitive deficits by Nrf2-mediated antioxidative pathway and provides neuroprotection against amyloid-beta-induced mitochondria dysfunction. It enhances SOD and catalase activities and scavenges reactive oxygen species to protect the cellular organelle from oxidative stress. It normalizes the tubulin protein and improved axonal growth by regulating nerve growth factors. Fenugreek can also influence metabolism.

Discussion: Fenugreek significantly improves the pathological symptoms of neurodegenerative disease, especially AD and can be used as a therapeutic agent to control disease conditions as evidenced by the review of the literature.

胡芦巴对阿尔茨海默病的药理作用。
背景:一年生植物葫芦巴(Trigonellafoenum-graecum L.)在阿育吠陀医学和中医中具有众所周知的保健作用。它的叶子和种子含有生物碱、氨基酸、豆黄素、类黄酮、皂苷和其他生物活性成分。胡芦巴具有抗氧化剂、降血糖和降血脂等多种药理特性。葫芦巴碱、薯蓣皂苷元和4-羟基异亮氨酸已显示出抗阿尔茨海默病的神经保护作用,据报道,其提取物还具有抗抑郁、抗焦虑和调节认知功能的作用。这篇综述重点介绍了在动物和人类身上进行的各种研究,以预防阿尔茨海默病。方法:本综述中的数据来自流行的搜索引擎,即Google Scholar、PubMed和Scopus。本文综述了2005年至2023年胡芦巴对神经退行性疾病(特别是AD)的保护作用的研究和临床试验。结果:胡芦巴通过nrf2介导的抗氧化途径改善认知缺陷,并对淀粉样蛋白诱导的线粒体功能障碍提供神经保护。提高SOD和过氧化氢酶活性,清除活性氧,保护细胞器免受氧化应激。它通过调节神经生长因子使微管蛋白正常化,促进轴突生长。胡芦巴还能影响新陈代谢。讨论:文献综述表明,胡芦巴能显著改善神经退行性疾病,尤其是AD的病理症状,可作为控制疾病病情的治疗剂。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current Alzheimer research
Current Alzheimer research 医学-神经科学
CiteScore
4.00
自引率
4.80%
发文量
64
审稿时长
4-8 weeks
期刊介绍: Current Alzheimer Research publishes peer-reviewed frontier review, research, drug clinical trial studies and letter articles on all areas of Alzheimer’s disease. This multidisciplinary journal will help in understanding the neurobiology, genetics, pathogenesis, and treatment strategies of Alzheimer’s disease. The journal publishes objective reviews written by experts and leaders actively engaged in research using cellular, molecular, and animal models. The journal also covers original articles on recent research in fast emerging areas of molecular diagnostics, brain imaging, drug development and discovery, and clinical aspects of Alzheimer’s disease. Manuscripts are encouraged that relate to the synergistic mechanism of Alzheimer''s disease with other dementia and neurodegenerative disorders. Book reviews, meeting reports and letters-to-the-editor are also published. The journal is essential reading for researchers, educators and physicians with interest in age-related dementia and Alzheimer’s disease. Current Alzheimer Research provides a comprehensive ''bird''s-eye view'' of the current state of Alzheimer''s research for neuroscientists, clinicians, health science planners, granting, caregivers and families of this devastating disease.
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