Immunological Facet and Inception after Post-COVID-19 Vaccination.

Q3 Pharmacology, Toxicology and Pharmaceutics
Suman Kumar Ray, Sukhes Mukherjee
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引用次数: 0

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induced coronavirus disease 2019 (COVID-19) pandemic has produced an unparalleled setback for the world's economy and health. One of the best therapies to significantly lower severe illness and mortality from SARS-CoV-2 infection is vaccination. Worldwide vaccination campaigns are being implemented. New-onset autoimmune problems, such as immune thrombotic thrombocytopenia, autoimmune liver disorders, IgA nephropathy, Guillain-Barré syndrome, systemic lupus erythematosus, and rheumatoid arthritis, have recently been described more frequently after receiving COVID-19 vaccine. The creation of specific autoantibodies, molecular mimicry, and the function of specific vaccine adjuvants all emerge to play a significant role in autoimmunity. The post-acute sequelae of SARS-CoV-2, usually known as Long Covid Syndrome, are beginning to be better understood in terms of the disparities in immune responses seen in individuals with and without the condition. We anticipate that the knowledge gleaned from several COVID-19 investigations will be put to use in research on the inflammatory mechanisms implicated in serious and protracted illnesses, which is still a key unmet need.

covid -19疫苗接种后的免疫学方面和初始阶段。
2019年严重急性呼吸系统综合征(SARS-CoV-2)引发的冠状病毒病(COVID-19)大流行给世界经济和健康带来了前所未有的挫折。显著降低SARS-CoV-2感染导致的严重疾病和死亡率的最佳疗法之一是接种疫苗。正在实施世界范围的疫苗接种运动。新发自身免疫性问题,如免疫性血栓性血小板减少症、自身免疫性肝病、IgA肾病、格林-巴罗综合征、系统性红斑狼疮和类风湿性关节炎,最近在接种COVID-19疫苗后被描述得更为频繁。特异性自身抗体的产生、分子模仿和特异性疫苗佐剂的功能都在自身免疫中发挥重要作用。SARS-CoV-2的急性后后遗症,通常被称为长冠综合征,从患者和非患者的免疫反应差异来看,人们开始更好地了解这种疾病。我们预计,从几项COVID-19调查中收集到的知识将用于研究与严重和长期疾病有关的炎症机制,这仍然是一个未得到满足的关键需求。
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来源期刊
Infectious disorders drug targets
Infectious disorders drug targets Pharmacology, Toxicology and Pharmaceutics-Pharmacology
CiteScore
3.10
自引率
0.00%
发文量
123
期刊介绍: Infectious Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in infectious disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in infectious disorders. As the discovery, identification, characterization and validation of novel human drug targets for anti-infective drug discovery continues to grow, this journal will be essential reading for all pharmaceutical scientists involved in drug discovery and development.
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