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{"title":"Adipose Tissue Plasticity in Aging.","authors":"Guan Wang, Anying Song, Marie Bae, Qiong A Wang","doi":"10.1002/cphy.c220005","DOIUrl":null,"url":null,"abstract":"<p><p>As a dynamic endocrine organ, white adipose tissue (WAT) stores lipids and plays a critical role in maintaining whole-body energy homeostasis and insulin sensitivity. A large group of the population over 65 years old suffer from increased WAT mass, especially in the visceral location. Visceral adiposity accelerates aging through promoting age-associated chronic conditions, significantly shortening life expectancy. Unlike WAT, brown adipose tissue (BAT) functions as an effective energy sink that burns and disposes of excess lipids and glucose upon activation of thermogenesis. Unfortunately, the thermogenic activity of BAT declines during aging. New appreciation of cellular and functional remodeling of WAT and BAT during aging has emerged in recent years. Efforts are underway to explore the potential underlying mechanisms behind these age-associated alterations in WAT and BAT and the impact of these alterations on whole-body metabolism. Lastly, it is intriguing to translate our knowledge obtained from animal models to the clinic to prevent and treat age-associated metabolic disorders. © 2022 American Physiological Society. Compr Physiol 12: 4119-4132, 2022.</p>","PeriodicalId":10573,"journal":{"name":"Comprehensive Physiology","volume":"12 4","pages":"4119-4132"},"PeriodicalIF":4.2000,"publicationDate":"2022-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comprehensive Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/cphy.c220005","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
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Abstract
As a dynamic endocrine organ, white adipose tissue (WAT) stores lipids and plays a critical role in maintaining whole-body energy homeostasis and insulin sensitivity. A large group of the population over 65 years old suffer from increased WAT mass, especially in the visceral location. Visceral adiposity accelerates aging through promoting age-associated chronic conditions, significantly shortening life expectancy. Unlike WAT, brown adipose tissue (BAT) functions as an effective energy sink that burns and disposes of excess lipids and glucose upon activation of thermogenesis. Unfortunately, the thermogenic activity of BAT declines during aging. New appreciation of cellular and functional remodeling of WAT and BAT during aging has emerged in recent years. Efforts are underway to explore the potential underlying mechanisms behind these age-associated alterations in WAT and BAT and the impact of these alterations on whole-body metabolism. Lastly, it is intriguing to translate our knowledge obtained from animal models to the clinic to prevent and treat age-associated metabolic disorders. © 2022 American Physiological Society. Compr Physiol 12: 4119-4132, 2022.
衰老过程中脂肪组织的可塑性。
白色脂肪组织(WAT)作为一种动态内分泌器官,储存脂质,在维持全身能量稳态和胰岛素敏感性方面起着至关重要的作用。65岁以上的人群中有很大一部分人患有WAT肿块,尤其是在内脏部位。内脏脂肪通过促进与年龄相关的慢性疾病加速衰老,显著缩短预期寿命。与WAT不同,棕色脂肪组织(BAT)作为一种有效的能量汇,在生热激活时燃烧和处理多余的脂质和葡萄糖。不幸的是,BAT的生热活性随着年龄的增长而下降。近年来,人们对WAT和BAT在衰老过程中的细胞和功能重塑有了新的认识。目前正在努力探索WAT和BAT这些年龄相关改变背后的潜在机制,以及这些改变对全身代谢的影响。最后,将我们从动物模型中获得的知识转化为临床预防和治疗与年龄相关的代谢紊乱是很有趣的。©2022美国生理学会。中国生物医学工程学报(英文版),2016。
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