Paying the Iron Price: Liver Iron Homeostasis and Metabolic Disease.

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Magdalene Ameka, Alyssa H Hasty
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引用次数: 4

Abstract

Iron is an essential metal element whose bioavailability is tightly regulated. Under normal conditions, systemic and cellular iron homeostases are synchronized for optimal function, based on the needs of each system. During metabolic dysfunction, this synchrony is lost, and markers of systemic iron homeostasis are no longer coupled to the iron status of key metabolic organs such as the liver and adipose tissue. The effects of dysmetabolic iron overload syndrome in the liver have been tied to hepatic insulin resistance, nonalcoholic fatty liver disease, and nonalcoholic steatohepatitis. While the existence of a relationship between iron dysregulation and metabolic dysfunction has long been acknowledged, identifying correlative relationships is complicated by the prognostic reliance on systemic measures of iron homeostasis. What is lacking and perhaps more informative is an understanding of how cellular iron homeostasis changes with metabolic dysfunction. This article explores bidirectional relationships between different proteins involved in iron homeostasis and metabolic dysfunction in the liver. © 2022 American Physiological Society. Compr Physiol 12:3641-3663, 2022.

Abstract Image

付出铁的代价:肝铁稳态与代谢疾病。
铁是一种重要的金属元素,其生物利用度受到严格调控。在正常情况下,根据每个系统的需要,系统和细胞的铁稳态是同步的,以达到最佳功能。在代谢功能障碍期间,这种同步性丧失,全身铁稳态的标志物不再与关键代谢器官(如肝脏和脂肪组织)的铁状态相耦合。肝脏代谢异常铁超载综合征的影响与肝脏胰岛素抵抗、非酒精性脂肪性肝病和非酒精性脂肪性肝炎有关。虽然铁调节失调和代谢功能障碍之间的关系早已被承认,但由于对铁体内平衡的预测依赖于系统性测量,确定相关关系变得复杂。对细胞铁稳态如何随着代谢功能障碍而改变的理解是缺乏的,也许更有意义。本文探讨了参与铁稳态和肝脏代谢功能障碍的不同蛋白之间的双向关系。©2022美国生理学会。中国生物医学工程学报(英文版),2012。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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