State of Knowledge on Molecular Adaptations to Exercise in Humans: Historical Perspectives and Future Directions.

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Kaleen M Lavin, Paul M Coen, Liliana C Baptista, Margaret B Bell, Devin Drummer, Sara A Harper, Manoel E Lixandrão, Jeremy S McAdam, Samia M O'Bryan, Sofhia Ramos, Lisa M Roberts, Rick B Vega, Bret H Goodpaster, Marcas M Bamman, Thomas W Buford
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Abstract

For centuries, regular exercise has been acknowledged as a potent stimulus to promote, maintain, and restore healthy functioning of nearly every physiological system of the human body. With advancing understanding of the complexity of human physiology, continually evolving methodological possibilities, and an increasingly dire public health situation, the study of exercise as a preventative or therapeutic treatment has never been more interdisciplinary, or more impactful. During the early stages of the NIH Common Fund Molecular Transducers of Physical Activity Consortium (MoTrPAC) Initiative, the field is well-positioned to build substantially upon the existing understanding of the mechanisms underlying benefits associated with exercise. Thus, we present a comprehensive body of the knowledge detailing the current literature basis surrounding the molecular adaptations to exercise in humans to provide a view of the state of the field at this critical juncture, as well as a resource for scientists bringing external expertise to the field of exercise physiology. In reviewing current literature related to molecular and cellular processes underlying exercise-induced benefits and adaptations, we also draw attention to existing knowledge gaps warranting continued research effort. © 2021 American Physiological Society. Compr Physiol 12:3193-3279, 2022.

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关于人类运动分子适应性的知识现状:历史展望与未来方向。
几个世纪以来,经常锻炼被认为是促进、维持和恢复人体几乎所有生理系统健康功能的有效刺激。随着人们对人体生理学复杂性的认识不断加深,方法论的可能性不断发展,以及日益严峻的公共卫生形势,将运动作为预防或治疗手段的研究从未像现在这样跨学科,也从未像现在这样影响深远。在美国国立卫生研究院共同基金(NIH Common Fund)"体育锻炼分子传导者联盟"(MoTrPAC)计划的早期阶段,该领域已做好充分准备,在现有对运动相关益处的内在机制的理解的基础上进行深入研究。因此,我们提出了一个全面的知识体系,详细介绍了当前围绕人类运动分子适应性的文献基础,以在这一关键时刻提供该领域的现状,并为将外部专业知识引入运动生理学领域的科学家提供资源。在回顾与运动引起的益处和适应性的分子和细胞过程相关的现有文献时,我们还提请注意需要继续研究的现有知识差距。© 2021 美国生理学会。Compr Physiol 12:3193-3279, 2022.
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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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