The Regulation of Germline Sex Determination in Drosophila by Sex lethal.

IF 2.4 4区医学 Q2 DEVELOPMENTAL BIOLOGY

Sexual Development Pub Date : 2022-01-01 Epub Date: 2022-03-08 DOI:10.1159/000521235

Lydia Grmai, Caitlin Pozmanter, Mark Van Doren

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引用次数: 5

Abstract

Background: The establishment of male or female identity (sex determination) is essential for creating the anatomical, physiological, and behavioral differences between 2 sexes of the same species (sexual dimorphism). In many organisms, including mammals and Drosophila, sex is determined by inheritance of sex chromosomes, while in other animals, sex is determined by environmental factors. Arguably the most important consequence of sex determination is the production of healthy gametes necessary for reproduction: female oocytes and male spermatids.

Summary: The generation of sperm and oocytes requires cooperation between 2 different cell types within the gonad: germ cells and somatic cells. Defects in sex determination in either the somatic gonad or germline lead to disorders of sexual development and infertility. In Drosophila, the gene Sex lethal (Sxl) is the key determinant of sex in both the soma and the germline. However, how Sxl controls sex determination is much more well understood in the soma than the germline. Key Mesage: This review will focus on Sxl in the germline, how it is activated specifically in female germ cells, and how it regulates germline sex determination and sexual development.

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性别致死对果蝇生殖系性别决定的调控。

背景：建立男性或女性身份（性别决定）对于在同一物种的两种性别之间产生解剖学、生理学和行为差异（两性异形）至关重要。在许多生物中，包括哺乳动物和果蝇，性别由性染色体的遗传决定，而在其他动物中，性别由环境因素决定。可以说，性别决定最重要的结果是产生生殖所需的健康配子：雌性卵母细胞和雄性精子细胞。摘要：精子和卵母细胞的产生需要性腺内两种不同细胞类型的合作：生殖细胞和体细胞。体细胞性腺或生殖系的性别决定缺陷会导致性发育障碍和不孕。在果蝇中，性致死基因（Sxl）是体细胞和种系性别的关键决定因素。然而，Sxl如何控制性别决定在体细胞中比在种系中更为清楚。Key Mesage：这篇综述将重点关注生殖系中的Sxl，它如何在女性生殖细胞中被特异性激活，以及它如何调节生殖系性别决定和性发育。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Sexual Development 生物-发育生物学

CiteScore

4.00

自引率

4.30%

发文量

审稿时长

>12 weeks

期刊介绍： Recent discoveries in experimental and clinical research have led to impressive advances in our knowledge of the genetic and environmental mechanisms governing sex determination and differentiation, their evolution as well as the mutations or endocrine and metabolic abnormalities that interfere with normal gonadal development. ‘Sexual Development’ provides a unique forum for this rapidly expanding field. Its broad scope covers all aspects of genetics, molecular biology, embryology, endocrinology, evolution and pathology of sex determination and differentiation in humans and animals. It publishes high-quality original research manuscripts, review articles, short reports, case reports and commentaries. An internationally renowned and multidisciplinary editorial team of three chief editors, ten prominent scientists serving as section editors, and a distinguished panel of editorial board members ensures fast and author-friendly editorial processing and peer reviewing.