The impact of epigenetic landscape on ovarian cells in infertile older women undergoing IVF procedures.

IF 5.7 2区医学 Q1 Medicine

Clinical Epigenetics Pub Date : 2023-05-04 DOI:10.1186/s13148-023-01490-0

Giulia Sgueglia, Salvatore Longobardi, Domenico Valerio, Maria Rosaria Campitiello, Nicola Colacurci, Cinzia Di Pietro, Rosalia Battaglia, Thomas D'Hooghe, Lucia Altucci, Carmela Dell'Aversana

引用次数: 0

Abstract

The constant decline in fertility and older reproductive age is the major cause of low clinical pregnancy rates in industrialised countries. Epigenetic mechanisms impact on proper embryonic development in women undergoing in vitro fertilisation (IVF) protocols. Here, we describe the main epigenetic modifications that may influence female reproduction and could affect IVF success.

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表观遗传景观对接受体外受精手术的不孕老年妇女卵巢细胞的影响。

生育率的持续下降和生育年龄的延长是工业化国家临床怀孕率低的主要原因。表观遗传机制对接受体外受精(IVF)方案的妇女胚胎发育的影响。在这里，我们描述了可能影响女性生殖并可能影响试管婴儿成功的主要表观遗传修饰。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Epigenetics Biochemistry, Genetics and Molecular Biology-Developmental Biology

CiteScore

8.90

自引率

5.30%

发文量

150

审稿时长

12 weeks

期刊介绍： Clinical Epigenetics, the official journal of the Clinical Epigenetics Society, is an open access, peer-reviewed journal that encompasses all aspects of epigenetic principles and mechanisms in relation to human disease, diagnosis and therapy. Clinical trials and research in disease model organisms are particularly welcome.