Salivary biomarkers as potential diagnostic tool for temporomandibular disorders: A comprehensive review.

IF 2 4区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Cranio-The Journal of Craniomandibular & Sleep Practice Pub Date : 2025-07-01 Epub Date: 2023-07-12 DOI:10.1080/08869634.2023.2229607

Yasmina Aoun, Rita Ejbeh, Abboud Youssef, Joseph Hobeiche

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引用次数: 0

Abstract

Objective: To review the current scientific literature concerning the implication of biomarkers collected from saliva in the diagnosis of temporomandibular disorders (TMD).

Methods: A comprehensive literature search was conducted on PubMed, Google Scholar, Embase, MEDLINE and Web of Science to gather articles published between 2012 and 2021. Based on the eligibility criteria, articles were reviewed in full and precise data was extracted.

Results: Nine clinical studies were selected. Participants with TMD were all diagnosed according to the Diagnostic Criteria for Temporomandibular Disorders. Specific biomarkers were examined from saliva samples. Results related to TMD showed a significant range of variability.

Conclusion: Specific salivary biomarkers have been investigated, but current efforts are aiming to search for more possible biomarkers from saliva samples as a safe procedure. Future research needs to consider the sensitivity and specificity of these biomarkers as diagnostic tools for TMD.

查看原文本刊更多论文

唾液生物标志物作为颞下颌疾病的潜在诊断工具：全面回顾。

目的：综述目前有关唾液生物标志物在颞下颌疾病（TMD）诊断中的意义的科学文献。方法：综合检索PubMed、b谷歌Scholar、Embase、MEDLINE和Web of Science等数据库，收集2012 - 2021年间发表的文章。根据入选标准，对文章进行了全面的审查，并提取了准确的数据。结果：9项临床研究入选。TMD患者均根据颞下颌疾病诊断标准进行诊断。从唾液样本中检测特定的生物标志物。与TMD相关的结果显示了显著的变异性。结论：特定的唾液生物标志物已经被研究过，但目前的努力是为了从唾液样本中寻找更多可能的生物标志物，作为一种安全的程序。未来的研究需要考虑这些生物标志物作为TMD诊断工具的敏感性和特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cranio-The Journal of Craniomandibular & Sleep Practice DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

4.50

自引率

12.50%

发文量

审稿时长

>12 weeks

期刊介绍： CRANIO: The Journal of Craniomandibular & Sleep Practice is the oldest and largest journal in the world devoted to temporomandibular disorders, and now also includes articles on all aspects of sleep medicine. The Journal is multidisciplinary in its scope, with editorial board members from all areas of medicine and dentistry, including general dentists, oral surgeons, orthopaedists, radiologists, chiropractors, professors and behavioural scientists, physical therapists, acupuncturists, osteopathic and ear, nose and throat physicians. CRANIO publishes commendable works from outstanding researchers and clinicians in their respective fields. The multidisciplinary format allows individuals practicing with a TMD emphasis to stay abreast of related disciplines, as each issue presents multiple topics from overlapping areas of interest. CRANIO''s current readership (thousands) is comprised primarily of dentists; however, many physicians, physical therapists, chiropractors, osteopathic physicians and other related specialists subscribe and contribute to the Journal.