Coexistence of human immunodeficiency virus infection and autoimmune hepatitis: A double trouble.

IF 0.6 Q4 INFECTIOUS DISEASES

Indian Journal of Sexually Transmitted Diseases and AIDS Pub Date : 2023-01-01 Epub Date: 2022-12-09 DOI:10.4103/ijstd.ijstd_73_22

Manish Manrai, Rohit Vashisht, Balakrishnan Arivalagan, Puneet Baveja, Ahmed Waheed Kashif, Anil Menon

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引用次数: 0

Abstract

A wide spectrum of hepatobiliary manifestations occur in Human Immunodeficiency Virus (HIV)-infected patients. Among the common causes are the infectious hepatitis, drug-related hepatitis, opportunistic infections, non-alcoholic steatohepatitis, HIV cholangiopathy and neoplasm. Auto-immune hepatitis (AIH) is rarely reported in this setting. We present two different presentations of auto immune hepatitis in HIV positive patients. One developed jaundice and ascites as a consequence of liver decompensation and other exhibited cholestatic pattern. Their serology and liver biopsy confirmed autoimmune hepatitis as underlying aetiology. We would like to share the clinical improvement with simultaneous immunosuppressive therapy and combination Anti Retroviral Therapy (cART). There are no documented cases on this issue from the Indian subcontinent that we are aware of.

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人类免疫缺陷病毒感染和自身免疫性肝炎共存：双重麻烦。

人类免疫缺陷病毒（HIV）感染患者有广泛的肝胆表现。常见原因包括感染性肝炎、药物相关肝炎、机会性感染、非酒精性脂肪性肝炎、HIV胆道病和肿瘤。自身免疫性肝炎（AIH）在这种情况下很少报道。我们对HIV阳性患者自身免疫性肝炎提出了两种不同的表现。其中一例因肝脏失代偿而出现黄疸和腹水，另一例表现为胆汁淤积型。他们的血清学和肝活检证实自身免疫性肝炎是潜在的病因。我们想分享同时免疫抑制治疗和联合抗逆转录病毒治疗（cART）的临床改进。据我们所知，印度次大陆没有关于这一问题的记录在案的案例。

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来源期刊

Indian Journal of Sexually Transmitted Diseases and AIDS INFECTIOUS DISEASES-

CiteScore

0.60

自引率

25.00%

发文量