Histopathological parameters reported in microinvasive oral squamous cell carcinoma: a systematic review.

IF 2.2 3区医学

Medicina oral, patologia oral y cirugia bucal Pub Date : 2023-05-01 DOI:10.4317/medoral.25675

C Saldivia-Siracusa, A-L Araújo, W-A González-Arriagada, F-J Nava, K-D Hunter, M-A Lopes, P-A Vargas, A-R Santos-Silva

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引用次数: 1

Abstract

Background: Microinvasive oral squamous cell carcinoma (OSCCmi) is an incipient stage of oral cancer. Through this systematic review, we aim to assess patterns of histopathological outcomes reported in OSCCmi cases.

Material and methods: An online search in major databases was performed without period restriction, and 2,024 publications in English, Spanish and Portuguese were obtained. After screening and eligibility, 4 studies were selected. The risk of bias was assessed using Joanna Briggs Institute Critical Appraisal Checklist. A descriptive synthesis was conducted.

Results: All 4 publications included were retrospective, reporting a total of 116 OSCCmi patients, with a male predominance (1.6:1) and a mean age of 55.9 years. The main parameters considered for microinvasion were tumor thickness (TT) (range 4-10mm) and depth of invasion (DOI) (range 0,02-5mm). Definition, cut-off values, and assessment of microscopic features were not standardized. Other relevant measures such as perineural or lymphovascular invasion and pattern of invasive front were barely described, and cytological/architectural characteristics were not discussed.

Conclusions: TT and DOI are currently the primary histopathological criteria used to define OSCCmi. Nonetheless, the outcomes of this systematic review showed the absence of standardized quantitative parameters to render the diagnosis of microinvasive OSCC. Therefore, additional studies aiming to standardize histopathological features to diagnose OSCCmi are paramount.

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微创口腔鳞状细胞癌的组织病理学参数报告:一项系统综述。

背景:微创口腔鳞状细胞癌(Microinvasive oral squamous cell carcinoma, OSCCmi)是一种早期的口腔癌。通过这一系统综述，我们旨在评估OSCCmi病例报告的组织病理学结果模式。材料和方法:在各大数据库中进行无时期限制的在线检索，获得英文、西班牙文和葡萄牙文出版物2024篇。经筛选合格后，入选4项研究。偏倚风险采用乔安娜布里格斯研究所关键评估清单进行评估。进行了描述性综合。结果:纳入的4篇文献均为回顾性研究，共报道了116例OSCCmi患者，男性占多数(1.6:1)，平均年龄55.9岁。微侵袭的主要参数为肿瘤厚度(TT)(范围4-10mm)和浸润深度(DOI)(范围0.02 -5mm)。定义、临界值和微观特征评估没有标准化。其他相关措施，如神经周围或淋巴血管侵犯和侵犯前缘的模式几乎没有描述，细胞学/建筑学特征没有讨论。结论:TT和DOI是目前用于定义OSCCmi的主要组织病理学标准。尽管如此，本系统综述的结果显示缺乏标准化的定量参数来诊断微创OSCC。因此，旨在标准化组织病理学特征来诊断OSCCmi的进一步研究是至关重要的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina oral, patologia oral y cirugia bucal Medicine-Surgery

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology