[Hypothyroidism and aging: the search for protective factors].

Q4 Medicine
A K Ilyushchenko, L V Machekhina, E N Dudinskaya
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引用次数: 1

Abstract

Searching for aging key points is one of the main problems in geriatrics. More and more research in recent years has been devoted to the study of geroprotective mechanisms, the impact of various conditions and diseases on aging in general. Of particular importance is the determination of age-related involutive processes in the human body, whether they are part of normal aging or a condition that needs to be corrected to improve the functioning of organs and systems. An important mechanism of aging starts is a change in hormonal activity of endocrine glands, in particular in hormonal activity of thyroid. Frequency of hypothyroidism in advanced age explains relevance of the chosen topic. The aim of the review was to find out the role hypothyroidism in aging. The main task was to define, whether thyroid hormones decrease in older age was a protective factor or pathological process. A review of the literature over the past 10 years on subclinical treatment was carried out and we identified the most pressing issues associated with hypothyroidism and aging. We studied data on the relationship between hypothyroidism and major geriatric syndromes, with special attention paid to cognitive diseases and emotional disorders.

[甲状腺功能减退和衰老:寻找保护因素]。
寻找衰老关键点是老年病学的主要问题之一。近年来,越来越多的研究致力于研究衰老保护机制,各种条件和疾病对衰老的影响。特别重要的是确定人体中与年龄相关的相互作用过程,无论它们是正常衰老的一部分,还是需要纠正以改善器官和系统的功能。衰老开始的一个重要机制是内分泌腺激素活性的变化,尤其是甲状腺激素活性的变化。高龄甲状腺功能减退的频率解释了所选主题的相关性。本综述的目的是了解甲状腺功能减退在衰老中的作用。主要任务是确定老年甲状腺激素下降是一种保护因素还是病理过程。回顾了过去10年亚临床治疗的文献,我们确定了与甲状腺功能减退和衰老相关的最紧迫的问题。我们研究了甲状腺功能减退与主要老年综合征之间的关系,特别关注认知疾病和情绪障碍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Problemy endokrinologii
Problemy endokrinologii Medicine-Endocrinology, Diabetes and Metabolism
CiteScore
1.40
自引率
0.00%
发文量
59
期刊介绍: Since 1955 the “Problems of Endocrinology” (or “Problemy Endocrinologii”) Journal publishes timely articles, balancing both clinical and experimental research, case reports, reviews and lectures on pressing problems of endocrinology. The Journal is aimed to the most topical issues of endocrinology: to chemical structure, biosynthesis and metabolism of hormones, the mechanism of their action at cellular and molecular level; pathogenesis and to clinic of the endocrine diseases, new methods of their diagnostics and treatment. The Journal: features original national and foreign research articles, reflecting world endocrinology development; issues thematic editions on specific areas; publishes chronicle of major international congress sessions and workshops on endocrinology, as well as state-of-the-art guidelines; is intended for scientists, endocrinologists diabetologists and specialists of allied trade, general practitioners, family physicians and pediatrics.
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