Mannose-binding lectin (MBL) levels in children with Hashimoto's thyroiditis.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Ali Gul, Nihal Hatipoglu, Resul Yilmaz, Haci Omer Ates
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Abstract

Objective: Hashimoto's thyroiditis (HT) was described many years ago, but the etiopathogenesis remains unclear. Mannose-binding lectin (MBL) initiates complement activation in the lectin pathway. We determined MBL levels in children with HT and the associations thereof with thyroid hormone and thyroid autoantibody levels.

Methods: Thirty-nine patients with HT and 41 controls were enrolled from the pediatric outpatient clinics. Subjects were grouped according to their thyroid functions: Euthyroid, marked hypothyroidism and clinical/subclinical hyperthyroidism. MBL levels were compared among these groups. Serum MBL levels of the subjects were determined using MBL Human ELISA kit.

Results: Serum MBL levels were studied in serum samples from the 80 subjects (48 (60.0%) females). MBL levels in HT and control groups were 50.787±34.718 and 50.593±44.28 ng/ml (p=0,983), respectively. In HT group, there was no significant difference in MBL levels between thyroid function groups (p=0.869). In addition, gender was not detected as a factor for serum MBL levels. Also we found negative correlation between WBC and serum MBL levels (r=-0.532; p=0.050). Otherwise there was no correlation between TSH, anti-TPO and anti-TG with serum MBL levels.

Conclusion: MBL levels did not decrease in HT patients. Further research is needed to elucidate more fully any role for MBL in the development of autoimmune thyroid disease.

甘露糖结合凝集素(MBL)在桥本甲状腺炎患儿中的水平。
目的:桥本甲状腺炎(桥本甲状腺炎)多年前被报道,但其病因尚不清楚。甘露糖结合凝集素(MBL)在凝集素途径中启动补体激活。我们测定了HT患儿的MBL水平及其与甲状腺激素和甲状腺自身抗体水平的关系。方法:从儿科门诊选取39例HT患者和41例对照组。根据受试者的甲状腺功能分为:甲状腺功能正常、明显甲状腺功能减退和临床/亚临床甲状腺功能亢进。比较各组间MBL水平。采用MBL人ELISA试剂盒测定受试者血清MBL水平。结果:对80例受试者(女性48例(60.0%))的血清MBL水平进行了研究。HT组和对照组MBL水平分别为50.787±34.718和50.593±44.28 ng/ml (p=0,983)。HT组甲状腺功能组间MBL水平差异无统计学意义(p=0.869)。此外,性别未被检测为血清MBL水平的一个因素。我们还发现WBC与血清MBL水平呈负相关(r=-0.532;p = 0.050)。此外,TSH、抗tpo和抗tg与血清MBL水平无相关性。结论:HT患者的MBL水平没有降低。需要进一步的研究来更充分地阐明MBL在自身免疫性甲状腺疾病发展中的任何作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
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