Resting-State Connectivity in Acute and Subacute Poststroke Aphasia: A Functional Near-Infrared Spectroscopy Pilot Study.

IF 2.4 3区 医学 Q3 NEUROSCIENCES
Brain connectivity Pub Date : 2023-10-01 Epub Date: 2023-05-15 DOI:10.1089/brain.2022.0065
Erin L Meier, Lisa D Bunker, Hana Kim, Argye E Hillis
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Abstract

Background: Understanding how brain function and language skills change during early (acute and subacute) stroke phases is critical for maximizing patient recovery, yet functional neuroimaging studies of early aphasia are scarce. In this pilot study, we used functional near-infrared spectroscopy (fNIRS) to investigate how resting-state functional connectivity (rs-FC) in early aphasia differs from neurologically healthy adults and is related to language deficits. Materials and Methods: Twenty individuals with aphasia (12 acute and 8 subacute phase) and 15 healthy controls underwent rs-fNIRS imaging with a 46-channel montage centered over bilateral perisylvian language areas. FC was computed using a prewhitening, autoregressive Pearson correlation routine applied to preprocessed oxyhemoglobin (HbO) data. Connections were classified as left intra-, right intra-, or interhemispheric. We then compared rs-FC between groups by connection type and examined Spearman correlations between rs-FC averages and language measures within patients. Results: Participants in the acute phase had significantly reduced global rs-FC across all HbO-based connections compared to healthy controls. No significant differences were found in rs-FC between controls and patients in the subacute phase. Controlling for days since stroke, stronger right intra- and interhemispheric rs-FC was related to milder aphasia across all patients. Exploratory correlations revealed that relationships between language measures and rs-FC differed between acute and subacute patient groups. Conclusion: This study provides preliminary evidence that fNIRS-based rs-FC measures may be a viable metric to index the early impacts of stroke in people with aphasia.

急性和亚急性脑卒中后失语症的静息状态连接性:一项功能性近红外光谱初步研究。
背景:了解早期(急性和亚急性)中风阶段大脑功能和语言技能的变化对于最大限度地提高患者的康复率至关重要,但早期失语症的功能性神经影像学研究很少。在这项初步研究中,我们使用功能性近红外光谱(fNIRS)来研究早期失语症的静息状态功能连接(rs-FC)与神经健康成年人的不同之处,以及与语言缺陷的关系。材料和方法:20名失语症患者(12名急性期和8名亚急性期)和15名健康对照者接受了以双侧侧脑室周围语言区为中心的46通道蒙太奇的rs-fNIRS成像。FC使用预白化、自回归Pearson相关程序计算,该程序应用于预处理的血红蛋白(HbO)数据。连接分为左半球内连接、右半球内连接或半球间连接。然后,我们根据连接类型比较了各组之间的rs FC,并检查了rs FC平均值与患者语言测量值之间的Spearman相关性。结果:与健康对照组相比,急性期参与者在所有基于HbO的连接中的全局rs FC显著降低。对照组和亚急性期患者的rs FC没有发现显著差异。在所有患者中,控制中风后的天数,右侧半球内和半球间rs FC更强与轻度失语症有关。探索性相关性显示,急性和亚急性患者组的语言测量和rs FC之间的关系不同。结论:本研究提供了初步证据,表明基于fNIRS的rs FC测量可能是一种可行的指标,可以用来衡量失语症患者中风的早期影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Brain connectivity
Brain connectivity Neuroscience-General Neuroscience
CiteScore
4.80
自引率
0.00%
发文量
80
期刊介绍: Brain Connectivity provides groundbreaking findings in the rapidly advancing field of connectivity research at the systems and network levels. The Journal disseminates information on brain mapping, modeling, novel research techniques, new imaging modalities, preclinical animal studies, and the translation of research discoveries from the laboratory to the clinic. This essential journal fosters the application of basic biological discoveries and contributes to the development of novel diagnostic and therapeutic interventions to recognize and treat a broad range of neurodegenerative and psychiatric disorders such as: Alzheimer’s disease, attention-deficit hyperactivity disorder, posttraumatic stress disorder, epilepsy, traumatic brain injury, stroke, dementia, and depression.
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