Pediatric intestine and multivisceral transplant.

IF 1.8 4区医学 Q3 TRANSPLANTATION

Current Opinion in Organ Transplantation Pub Date : 2023-08-01 Epub Date: 2023-06-12 DOI:10.1097/MOT.0000000000001082

Mohamed Maklad, George Mazariegos, Armando Ganoza

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引用次数: 0

Abstract

Purpose of review: Intestinal and multivisceral transplantation (ITx, MVTx) is the cornerstone in treatment of irreversible intestinal failure (IF) and complications related to parenteral nutrition. This review aims to highlight the unique aspects of the subject in pediatrics.

Recent findings: Etiology of intestinal failure (IF) in children shares some similarity with adults but several unique considerations when being evaluated for transplantation will be discussed. Owing to significant advancement in IF management and home parenteral nutrition (PN), indication criteria for pediatric transplantation continues to be updated. Outcomes have continued to improve with current long-term patient and graft survival in multicenter registry reports reported at 66.1% and 48.8% at 5 years, respectively. Pediatric specific surgical challenges such abdominal closure, post transplantation outcomes, and quality of life are discussed in this review.

Summary: ITx and MVTx remain lifesaving treatment for many children with IF. However long-term graft function is still a major challenge.

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小儿肠道和多脏器移植。

综述目的：肠道和多脏器移植（ITx，MVTx）是治疗不可逆肠道功能衰竭（IF）和肠外营养相关并发症的基石。本综述旨在强调儿科在这方面的独特之处：最近的研究结果：儿童肠功能衰竭（IF）的病因与成人有一些相似之处，但在接受移植评估时会有一些独特的考虑因素。由于肠功能衰竭治疗和家庭肠外营养（PN）的重大进展，儿科移植的适应症标准也在不断更新。移植结果不断改善，据多中心登记报告，目前患者和移植物5年的长期存活率分别为66.1%和48.8%。本综述讨论了小儿外科手术面临的挑战，如腹腔闭合、移植后疗效和生活质量。然而，长期移植功能仍是一项重大挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Opinion in Organ Transplantation 医学-移植

CiteScore

4.10

自引率

4.50%

发文量

124

审稿时长

6-12 weeks

期刊介绍： Current Opinion in Organ Transplantation is an indispensable resource featuring key, up-to-date and important advances in the field from around the world. Led by renowned guest editors for each section, every bimonthly issue of Current Opinion in Organ Transplantation delivers a fresh insight into topics such as stem cell transplantation, immunosuppression, tolerance induction and organ preservation and procurement. With 18 sections in total, the journal provides a convenient and thorough review of the field and will be of interest to researchers, surgeons and other healthcare professionals alike.