Salvage high-dose-rate interventional radiotherapy (brachytherapy) for locally relapsed prostate cancer after radical prostatectomy and subsequent external irradiation.

IF 1.1 4区 医学 Q4 ONCOLOGY
Tamer Soror, Corrina Melchert, Dirk Rades, Axel S Merseburger, György Kovács
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引用次数: 1

Abstract

Purpose: To report the use of high-dose-rate (HDR) interventional radiotherapy (brachytherapy, IRT) as a salvage treatment for macroscopic histologically confirmed local relapse of prostatic cancer after prostatectomy and subsequent external irradiation.

Material and methods: A retrospective study of patients with prostate adenocarcinoma, treated with HDR-IRT for an isolated local relapse after prostatectomy and external irradiation at our institution (2010-2020). Treatment results and treatment related-toxicity were recorded. Clinical outcomes were analyzed.

Results: Ten patients were identified. The median age was 63 years (range, 59-74 years), and the median follow-up time was 34 months (range, 10-68 months). Four patients had a biochemical relapse, and the mean time to prostate specific antigen (PSA) increase was 13 months. One-year biochemical failure-free survival (bFFS), 3-year bFFS, and 4-year bFFS were 80%, 60%, and 60%, respectively. Most of the treatment-related toxicities were grade 1-2. Two patients experienced grade 3 late genitourinary toxicity.

Conclusions: HDR-IRT seems to be an effective treatment option showing acceptable toxicity for prostate cancer patients with isolated macroscopic histologically confirmed local relapse after prostatectomy and subsequent external irradiation.

Abstract Image

Abstract Image

根治性前列腺切除术后局部复发前列腺癌的抢救性高剂量率介入放疗(近距离放疗)。
目的:报道高剂量率(HDR)介入放疗(brachytherapy, IRT)作为宏观组织学证实的前列腺癌切除术后外照射局部复发的补救性治疗。材料和方法:回顾性研究我院(2010-2020年)前列腺切除术和外照射后接受HDR-IRT治疗的孤立性局部复发前列腺癌患者。记录治疗结果及治疗相关毒性反应。分析临床结果。结果:确诊10例。中位年龄63岁(范围59 ~ 74岁),中位随访时间34个月(范围10 ~ 68个月)。4例患者生化复发,平均前列腺特异性抗原(PSA)升高时间为13个月。1年生化无故障生存率(bFFS)为80%,3年bFFS为60%,4年bFFS为60%。大多数治疗相关毒性为1-2级。2例患者出现3级晚期泌尿生殖系统毒性。结论:HDR-IRT似乎是一种有效的治疗选择,对于前列腺切除术和外照射后孤立的肉眼组织学证实的局部复发的前列腺癌患者具有可接受的毒性。
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来源期刊
Journal of Contemporary Brachytherapy
Journal of Contemporary Brachytherapy ONCOLOGY-RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
CiteScore
2.40
自引率
14.30%
发文量
54
审稿时长
16 weeks
期刊介绍: The “Journal of Contemporary Brachytherapy” is an international and multidisciplinary journal that will publish papers of original research as well as reviews of articles. Main subjects of the journal include: clinical brachytherapy, combined modality treatment, advances in radiobiology, hyperthermia and tumour biology, as well as physical aspects relevant to brachytherapy, particularly in the field of imaging, dosimetry and radiation therapy planning. Original contributions will include experimental studies of combined modality treatment, tumor sensitization and normal tissue protection, molecular radiation biology, and clinical investigations of cancer treatment in brachytherapy. Another field of interest will be the educational part of the journal.
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