Advancements in understanding mechanisms of hepatocellular carcinoma radiosensitivity: A comprehensive review.

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu Pub Date : 2023-06-30 DOI:10.21147/j.issn.1000-9604.2023.03.06

Gaoyuan Yang, Huamei Yan, Yongchang Tang, Feng Yuan, Mingbo Cao, Yupeng Ren, Yuxuan Li, Zhiwei He, Xiaorui Su, Zhicheng Yao, Meihai Deng

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Abstract

Primary liver cancer is a significant health problem worldwide. Hepatocellular carcinoma (HCC) is the main pathological type of primary liver cancer, accounting for 75%-85% of cases. In recent years, radiotherapy has become an emerging treatment for HCC and is effective for various stages of HCC. However, radiosensitivity of liver cancer cells has a significant effect on the efficacy of radiotherapy and is regulated by various factors. How to increase radiosensitivity and improve the therapeutic effects of radiotherapy require further exploration. This review summarizes the recent research progress on the mechanisms affecting sensitivity to radiotherapy, including epigenetics, transportation and metabolism, regulated cell death pathways, the microenvironment, and redox status, as well as the effect of nanoparticles on the radiosensitivity of liver cancer. It is expected to provide more effective strategies and methods for clinical treatment of liver cancer by radiotherapy.

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肝细胞癌放射敏感性机制研究进展综述

原发性肝癌是一个全球性的重大健康问题。肝细胞癌(HCC)是原发性肝癌的主要病理类型，占75%-85%的病例。近年来，放疗已成为HCC的一种新兴治疗方法，对肝癌的各个阶段都有效。然而，肝癌细胞的放射敏感性对放疗效果有显著影响，受多种因素调节。如何提高放射敏感性，提高放射治疗效果有待进一步探索。本文综述了近年来影响肝癌放疗敏感性的机制，包括表观遗传学、转运代谢、细胞死亡调控途径、微环境、氧化还原状态，以及纳米颗粒对肝癌放射敏感性的影响。期望为临床肝癌放疗治疗提供更有效的策略和方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Chinese journal of cancer research = Chung-kuo yen cheng yen chiu

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