Initial manifestations and risk factors for calcinosis in juvenile dermatomyositis: A retrospective multicenter study.

IF 0.9 Q3 MEDICINE, GENERAL & INTERNAL
Mustafa Cakan, Semanur Ozdel, Serife Gul Karadag, Kadir Ulu, Figen Cakmak, Gulcin Otar Yener, Kubra Ozturk, Esra Baglan, Hafize Emine Sonmez, Ferhat Demir, Betul Sozeri, Nuray Aktay Ayaz
{"title":"Initial manifestations and risk factors for calcinosis in juvenile dermatomyositis: A retrospective multicenter study.","authors":"Mustafa Cakan,&nbsp;Semanur Ozdel,&nbsp;Serife Gul Karadag,&nbsp;Kadir Ulu,&nbsp;Figen Cakmak,&nbsp;Gulcin Otar Yener,&nbsp;Kubra Ozturk,&nbsp;Esra Baglan,&nbsp;Hafize Emine Sonmez,&nbsp;Ferhat Demir,&nbsp;Betul Sozeri,&nbsp;Nuray Aktay Ayaz","doi":"10.14744/nci.2021.11129","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to look for the initial manifestations of juvenile dermatomyositis (JDM), give follow-up results, and search for risk factors for the development of calcinosis.</p><p><strong>Methods: </strong>The files of children with JDM diagnosed between 2005 and 2020 were reviewed retrospectively.</p><p><strong>Results: </strong>The study included 48 children, 33 girls and 15 boys. The mean age at the onset of the disease was 7.6±3.6 years. The median duration of follow-up was 35 (6-144) months. Twenty-nine patients (60.4%) had monocyclic, 7 (14.6%) patients had polycyclic, and 12 (25%) patients had chronic persistent disease course. At the time of enrollment, 35 (72.9%) patients were in remission, while 13 (27.1%) patients had active disease. Calcinosis developed in 11 patients (22.9%). Children having myalgia, livedo racemosa, skin hypopigmentation, lower alanine aminotransferase (ALT) levels, and higher physician visual analog scores at the time of diagnosis had a higher risk for calcinosis. Calcinosis was also more common in children with diagnostic delay and chronic persistent disease course. None of these parameters remained independent risk factors for calcinosis in multivariate logistic regression analysis.</p><p><strong>Conclusion: </strong>The rate of mortality has decreased dramatically over decades in JDM, but the rate of calcinosis has not changed proportionately. Long duration of active, untreated disease is accepted as the main risk factor for calcinosis. We have seen that calcinosis was more common in children having myalgia, livedo racemosa, skin hypopigmentation, lower ALT levels, and higher physician visual analog scores at the time of diagnosis.</p>","PeriodicalId":19164,"journal":{"name":"Northern Clinics of Istanbul","volume":null,"pages":null},"PeriodicalIF":0.9000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/a9/NCI-10-298.PMC10331242.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Northern Clinics of Istanbul","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.14744/nci.2021.11129","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MEDICINE, GENERAL & INTERNAL","Score":null,"Total":0}
引用次数: 0

Abstract

Objective: This study aimed to look for the initial manifestations of juvenile dermatomyositis (JDM), give follow-up results, and search for risk factors for the development of calcinosis.

Methods: The files of children with JDM diagnosed between 2005 and 2020 were reviewed retrospectively.

Results: The study included 48 children, 33 girls and 15 boys. The mean age at the onset of the disease was 7.6±3.6 years. The median duration of follow-up was 35 (6-144) months. Twenty-nine patients (60.4%) had monocyclic, 7 (14.6%) patients had polycyclic, and 12 (25%) patients had chronic persistent disease course. At the time of enrollment, 35 (72.9%) patients were in remission, while 13 (27.1%) patients had active disease. Calcinosis developed in 11 patients (22.9%). Children having myalgia, livedo racemosa, skin hypopigmentation, lower alanine aminotransferase (ALT) levels, and higher physician visual analog scores at the time of diagnosis had a higher risk for calcinosis. Calcinosis was also more common in children with diagnostic delay and chronic persistent disease course. None of these parameters remained independent risk factors for calcinosis in multivariate logistic regression analysis.

Conclusion: The rate of mortality has decreased dramatically over decades in JDM, but the rate of calcinosis has not changed proportionately. Long duration of active, untreated disease is accepted as the main risk factor for calcinosis. We have seen that calcinosis was more common in children having myalgia, livedo racemosa, skin hypopigmentation, lower ALT levels, and higher physician visual analog scores at the time of diagnosis.

青少年皮肌炎钙沉着症的初始表现和危险因素:一项回顾性多中心研究。
目的:本研究旨在探讨青少年皮肌炎(JDM)的初始表现,随访结果,寻找钙质沉着症发展的危险因素。方法:回顾性分析2005 ~ 2020年诊断为JDM的患儿资料。结果:本研究纳入48例儿童,其中女孩33例,男孩15例。发病的平均年龄为7.6±3.6岁。中位随访时间为35(6-144)个月。单环29例(60.4%),多环7例(14.6%),慢性病程持续12例(25%)。在入组时,35例(72.9%)患者处于缓解期,13例(27.1%)患者处于活动性疾病。11例(22.9%)发生钙质沉着症。患有肌痛、总状斑、皮肤色素沉着、谷丙转氨酶(ALT)水平较低和医生视觉模拟评分较高的儿童在诊断时罹患钙质沉着症的风险较高。钙质沉着症在诊断延迟和慢性持续性病程的儿童中也更为常见。在多变量logistic回归分析中,这些参数都不是钙质沉着症的独立危险因素。结论:近几十年来,JDM的死亡率显著下降,但钙质沉着率没有成比例变化。长期不治疗的活动性疾病被认为是钙质沉着症的主要危险因素。我们已经看到,钙质沉着症在患有肌痛、活状外翻、皮肤色素沉着、ALT水平较低和诊断时医生视觉模拟评分较高的儿童中更为常见。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Northern Clinics of Istanbul
Northern Clinics of Istanbul MEDICINE, GENERAL & INTERNAL-
CiteScore
0.40
自引率
0.00%
发文量
48
审稿时长
10 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信