[Classic Hodgkin lymphoma].

Shinichi Makita
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引用次数: 0

Abstract

Classic Hodgkin lymphoma (cHL) is one of the common subtypes of malignant lymphoma in Western countries. Although patients with HL showed unsatisfactory results in the 1960s, the clinical development in radiotherapy and chemotherapy based on several clinical trials over the last 50 years has made cHL a curable disease with a favorable outcome. As a result, late-onset treatment-related toxicities such as second primary malignancies and cardiac events are thought to be a significant issue especially in early-stage patients. To minimize the toxic effects while maximizing the antitumor efficacy, several clinical trials to evaluate response-adapted strategies using interim PET scans and novel agents, such as brentuximab vedotin (BV) and/or immune checkpoint inhibitor (ICI) are currently underway. In this review, the author summarizes currently available data on PET-adapted and BV and/or ICI-containing therapies for untreated cHL, and discusses their future prospects in cHL treatment.

[典型霍奇金淋巴瘤]。
经典霍奇金淋巴瘤(Classic Hodgkin lymphoma, cHL)是西方国家常见的恶性淋巴瘤亚型之一。尽管HL患者在20世纪60年代表现出不理想的结果,但近50年来基于多项临床试验的放疗和化疗的临床发展使cHL成为一种可治愈的疾病,预后良好。因此,迟发性治疗相关的毒性,如第二原发恶性肿瘤和心脏事件被认为是一个重要的问题,特别是在早期患者中。为了最大限度地减少毒性作用,同时最大限度地提高抗肿瘤疗效,目前正在进行一些临床试验,以评估使用中期PET扫描和新型药物(如brentuximab vedotin (BV)和/或免疫检查点抑制剂(ICI)的反应适应策略。在这篇综述中,作者总结了目前关于pet适应型和BV和/或含ci治疗未经治疗的cHL的现有数据,并讨论了它们在cHL治疗中的未来前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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