A study of efficacy of Nigella sativa in treatment of Meniere's disease: A randomized, placebo controlled clinical trial

IF 1.4 Q2 OTORHINOLARYNGOLOGY

Journal of Otology Pub Date : 2023-04-01 DOI:10.1016/j.joto.2023.02.002

Masoud Motesadi Zarandi , Zahra Rabbani , Mahtab Rabbani Anari , Ali Kouhi , Mona Zeinaloo

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引用次数: 0

Abstract

Purpose

Meniere's disease (MD), first introduced by Prosper Meniere, is characterized mainly by vertigo, tinnitus, aural fullness and sensorineural hearing loss. Though the exact pathophysiology of MD is unknown, immunologic and inflammatory interactions are possible underlying mechanisms involved in MD. This study is aimed to investigate the immunomodulatory and anti-inflammatory effect of Nigella sativa on MD as a therapeutic agent.

Methods

We divided 40 patients with definite MD into two groups of 20 cases. The study group received 1 g of Nigella sativa oil daily for three months and the control group received a placebo. Changes in hearing, tinnitus and vertigo were estimated by pure tone audiometry, tinnitus handicap inventory questionnaire and dizziness handicap inventory questionnaire, respectively.

Results

At the end of the study we did not observe any significant improvement in study's group hearing threshold, tinnitus and vertigo compared to the control group.

Conclusions

In this study, statistical analysis showed that Nigella sativa failed to improve signs and symptoms of MD. However, further investigations with a larger study population are needed to ascertain the current conclusion.

Abstract Image

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Nigella sativa治疗梅尼埃病的疗效研究：一项随机、安慰剂对照的临床试验

目的梅尼埃病（MD）由Prosper Meniere首次提出，主要表现为眩晕、耳鸣、听觉饱胀和感音神经性听力损失。虽然MD的确切病理生理学尚不清楚，但免疫和炎症相互作用可能是MD的潜在机制。本研究旨在研究Nigella sativa作为一种治疗剂对MD的免疫调节和抗炎作用。方法将40例确诊MD患者分为两组，每组20例。研究组在三个月内每天服用1克奈杰尔拉油，对照组服用安慰剂。分别采用纯音测听法、耳鸣障碍量表和眩晕障碍量表估计听力、耳鸣和眩晕的变化。结果研究结束时，与对照组相比，研究组的听阈、耳鸣和眩晕没有任何显著改善。结论在本研究中，统计分析表明，Nigella sativa未能改善MD的体征和症状。然而，需要对更多的研究人群进行进一步的调查来确定目前的结论。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Otology Medicine-Otorhinolaryngology

CiteScore

2.70

自引率

0.00%

发文量

461

审稿时长

18 days

期刊介绍： Journal of Otology is an open access, peer-reviewed journal that publishes research findings from disciplines related to both clinical and basic science aspects of auditory and vestibular system and diseases of the ear. This journal welcomes submissions describing original experimental research that may improve our understanding of the mechanisms underlying problems of basic or clinical significance and treatment of patients with disorders of the auditory and vestibular systems. In addition to original papers the journal also offers invited review articles on current topics written by leading experts in the field. The journal is of primary importance for all scientists and practitioners interested in audiology, otology and neurotology, auditory neurosciences and related disciplines. Journal of Otology welcomes contributions from scholars in all countries and regions across the world.