Allicin Protects Renal Function, Improves Oxidative Stress and Lipid Peroxidation in Rats with Chronic Renal Failure.

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2023-05-01

Ningning Xu, Weinan Han, Guoping Yun, Lulu Shi

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引用次数: 0

Abstract

Introduction: The research was an attempt to explore the potential impact of allicin on lipid peroxidation and oxidative stress in rats diagnosed with chronic kidney disease (CKD), and to determine its underlying mechanism.

Methods: Sixty rats were randomly divided into sham-operated, modelling, and allicin low, medium, and high dose groups. The histopathological structure of the kidney was observed in each group. Biochemical measurements were conducted to assess kidney function, including serum creatinine (Scr) and blood urea nitrogen (BUN), and 24-hour urine protein quantification. Levels of malondialdehyde (MDA), superoxide dismutase (SOD), reactive oxidative species (ROS), and reduced glutathione (GSH) in kidney tissue were measured, and mitogen-activated protein kinase (MAPK) and NF (nuclear factor) -κB protein levels were detected by western blotting.

Results: They showed that allicin improved the pathological structure of renal tissue and protected renal function by reducing oxidative stress and lipid peroxidation via targeting the ROS/ MAPK/NF-κB pathway. Allicin increased SOD and GSH levels, while decreasing Scr, MDA, ROS, BUN, and the amount of protein excreted in urine over a 24-hour in medium and high dose groups. MAPK and NF-κB protein levels in medium and high dose allicin groups were lower than the modelling group.

Conclusion: Based on the results, it can be inferred that allicin may safeguard renal function in rats with CKD and has the potential to serve as a treatment for kidney ailments. DOI: 10.52547/ijkd.7496.

本刊更多论文

大蒜素保护肾功能，改善慢性肾衰竭大鼠氧化应激和脂质过氧化。

本研究旨在探讨大蒜素对慢性肾脏疾病(CKD)大鼠脂质过氧化和氧化应激的潜在影响，并确定其潜在机制。方法:将60只大鼠随机分为假手术组、造模组和大蒜素低、中、高剂量组。观察各组肾脏组织病理结构。采用生化指标评估肾功能，包括血清肌酐(Scr)、血尿素氮(BUN)和24小时尿蛋白定量。检测肾脏组织中丙二醛(MDA)、超氧化物歧化酶(SOD)、活性氧(ROS)、还原性谷胱甘肽(GSH)水平，免疫印迹法检测丝裂原活化蛋白激酶(MAPK)和核因子-κB蛋白水平。结果:大蒜素通过靶向ROS/ MAPK/NF-κB通路，降低氧化应激和脂质过氧化，改善肾组织病理结构，保护肾功能。大蒜素增加了SOD和GSH水平，同时降低了24小时内Scr、MDA、ROS、BUN和尿中蛋白质排泄量。大蒜素中、高剂量组大鼠MAPK、NF-κB蛋白水平均低于模型组。结论:大蒜素对CKD大鼠的肾功能有一定的保护作用，具有治疗肾脏疾病的潜力。DOI: 10.52547 / ijkd.7496。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.