Evaluation of mouse behavioral responses to nutritive versus nonnutritive sugar using a deep learning-based 3D real-time pose estimation system.

IF 1.8 4区 医学 Q3 GENETICS & HEREDITY
Jineun Kim, Dae-Gun Kim, Wongyo Jung, Greg S B Suh
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引用次数: 1

Abstract

Animals are able to detect the nutritional content of sugar independently of taste. When given a choice between nutritive sugar and nonnutritive sugar, animals develop a preference for nutritive sugar over nonnutritive sugar during a period of food deprivation (Buchanan et al., 2022; Dus et al., 2011; 2015; Tan et al., 2020; Tellez et al., 2016). To quantify behavioral features during an episode of licking nutritive versus nonnutritive sugar, we implemented a multi-vision, deep learning-based 3D pose estimation system, termed the AI Vision Analysis for Three-dimensional Action in Real-Time (AVATAR)(Kim et al., 2022). Using this method, we found that mice exhibit significantly different approach behavioral responses toward nutritive sugar versus nonnutritive sugar even before licking a sugar solution. Notably, the behavioral sequences during the approach toward nutritive versus nonnutritive sugar became significantly different over time. These results suggest that the nutritional value of sugar not only promotes its consumption but also elicits distinct repertoires of feeding behavior in deprived mice.

使用基于深度学习的三维实时姿态估计系统评估小鼠对营养糖和非营养糖的行为反应。
动物能够独立于味道检测出糖的营养成分。当在营养糖和非营养糖之间做出选择时,动物在食物剥夺期间会对营养糖而不是非营养糖产生偏好(Buchanan et al., 2022;Dus等,2011;2015;Tan et al., 2020;Tellez等人,2016)。为了量化舔营养糖和非营养糖时的行为特征,我们实施了一个多视觉、基于深度学习的3D姿势估计系统,称为实时三维动作人工智能视觉分析(AVATAR)(Kim等人,2022)。使用这种方法,我们发现即使在舔糖溶液之前,小鼠对营养糖和非营养糖的接近行为反应也有显著差异。值得注意的是,在摄入营养糖和非营养糖的过程中,行为序列随着时间的推移变得明显不同。这些结果表明,糖的营养价值不仅促进了糖的消耗,而且在被剥夺的小鼠中引起了不同的摄食行为。
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来源期刊
Journal of neurogenetics
Journal of neurogenetics 医学-神经科学
CiteScore
4.40
自引率
0.00%
发文量
13
审稿时长
>12 weeks
期刊介绍: The Journal is appropriate for papers on behavioral, biochemical, or cellular aspects of neural function, plasticity, aging or disease. In addition to analyses in the traditional genetic-model organisms, C. elegans, Drosophila, mouse and the zebrafish, the Journal encourages submission of neurogenetic investigations performed in organisms not easily amenable to experimental genetics. Such investigations might, for instance, describe behavioral differences deriving from genetic variation within a species, or report human disease studies that provide exceptional insights into biological mechanisms
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