Hesperidin: A Potential Therapeutic Agent against COVID-19.

Q3 Pharmacology, Toxicology and Pharmaceutics

Current drug discovery technologies Pub Date : 2023-01-01 DOI:10.2174/1570163820666221017111556

Ashwani K Dhingra, Bhawna Chopra, Vaibhav Rathi, Sameer Sapra

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引用次数: 2

Abstract

COVID-19, aka Coronavirus Disease 2019, triggered by new severe acute respiratory syndrome coronavirus-2 or SARS-CoV-2, is now a public health emergency due to its rapid spread, high transmission efficiency, and severe viral pandemic that is significantly increasing the number of patients and associated deaths. Currently, no specific treatment is available for this highly contagious virus. The unavailability of effective and specific treatments and the severity of this epidemic situation potentiate medicinal chemists' in supporting new prophylactic or therapeutic interventions against COVID-19. This study discusses the therapeutic potential of hesperidin, a traditionally used herbal medicine with an exceptional safety profile. Recent studies on hesperidin advocate its promising potential in the prevention and management of COVID-19. This paper also discusses the recent clinical studies based on the previously documented antiviral activity of hesperidin. Herein, we propose the detailed preclinical and clinical manifestations of hesperidin based on its multifaceted bioactivities to develop a novel anti-COVID-19 lead.

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橙皮苷:新型冠状病毒肺炎的潜在治疗剂

由新型严重急性呼吸系统综合征冠状病毒-2或SARS-CoV-2引发的COVID-19，即2019年冠状病毒病，由于其传播迅速、传播效率高，以及严重的病毒大流行，导致患者人数和相关死亡人数显著增加，现已成为突发公共卫生事件。目前，尚无针对这种高传染性病毒的特异性治疗方法。由于缺乏有效和特异性的治疗方法，加上疫情的严重性，药物化学家有能力支持针对COVID-19的新的预防性或治疗性干预措施。本研究讨论了橙皮苷的治疗潜力，橙皮苷是一种传统使用的草药，具有特殊的安全性。近年来对橙皮苷的研究表明橙皮苷在COVID-19的预防和管理中具有广阔的潜力。本文还对近年来橙皮苷抗病毒活性的临床研究进行了讨论。本文基于橙皮苷的多方面生物活性，提出橙皮苷的临床前和临床表现，以开发新型抗covid -19先导物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current drug discovery technologies Pharmacology, Toxicology and Pharmaceutics-Drug Discovery

CiteScore

3.70

自引率

0.00%

发文量

期刊介绍： Due to the plethora of new approaches being used in modern drug discovery by the pharmaceutical industry, Current Drug Discovery Technologies has been established to provide comprehensive overviews of all the major modern techniques and technologies used in drug design and discovery. The journal is the forum for publishing both original research papers and reviews describing novel approaches and cutting edge technologies used in all stages of drug discovery. The journal addresses the multidimensional challenges of drug discovery science including integration issues of the drug discovery process.