Eco-Friendly UV-Spectrophotometric Methods Employing Magnetic Nano-Composite Polymer for the Extraction and Analysis of Sexual Boosters in Adulterated Food Products: Application of Computer-Aided Design.

IF 1.7 4区 农林科学 Q3 CHEMISTRY, ANALYTICAL
Mohamed A Abdelshakour, Khaled Attala, Ahmed Elsonbaty, Randa A Abdel Salam, Ghada M Hadad, Aziza E Mostafa, Maya S Eissa
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引用次数: 1

Abstract

Background: Solid phase extraction (SPE) techniques, based on computationally designed magnetic-based multi-targeting molecular imprinted polymer (MT-MIP), combined with UV spectrophotometric approaches provide advantages in the examination of counterfeit samples.

Objective: The current work describes an innovative and sustainable methodology for the simultaneous determination of tadalafil (TAD) and dapoxetine hydrochloride (DAP) in aphrodisiac counterfeit products (honey and instant coffee) utilizing SPE exploiting MT-MIP. Additionally, an innovative UV spectrophotometric method capable of resolving TAD in its pharmaceutical binary mixtures with DAP was developed. A novel computational approach was implemented to tailor the synthesis and design of the MT-MIP particles.

Methods: We applied a newly developed UV spectrophotometric method which was based on a Fourier self-deconvolution (FSD) method coupled with the isoabsorptive point for determination of TAD and DAP in pharmaceutical dosage form. We also applied an SPE process based on MT-MIP designed particles, assisting in the analysis of both drugs in counterfeit food samples. The SPE process and the UV spectroscopic methodology were assessed regarding their greenness using the pioneering green analytical procedure index (GAPI), analytical greeness including sample preparation (AGREEprep) and AGREE tools. The synthesized MT-MIP particles were characterized by scanning electron microscopy and energy-dispersive x-ray spectroscopy.

Results: The suggested spectrophotometric methods revealed a wide linear concentration range of 2-50 µg/mL with lower LODs in the range of 0.604-0.994 µg/mL. Additionally, the suggested method demonstrated the utmost sensitivity and eco-friendliness for their target in its mixed dosage form and counterfeit food products.

Conclusion: The SPE process and the developed analytical UV spectroscopic methodology were validated as per the ICH guidelines, and were found to be suitable for overseeing some counterfeiting activities in commercially available honey and instant coffee aphrodisiac products.

Highlights: An SPE method based on MT-MIP magnetic-based polymer and a UV spectroscopic method were successfully developed for analysis of TAD and DAP in different matrices.

磁性纳米复合聚合物紫外分光光度法提取分析掺假食品中的性促进剂:计算机辅助设计的应用
背景:固相萃取(SPE)技术基于计算设计的磁性多靶向分子印迹聚合物(MT-MIP),结合紫外分光光度法,在检测假冒样品方面具有优势。目的:本工作描述了一种创新和可持续的方法,利用SPE利用MT-MIP同时测定壮阳假冒产品(蜂蜜和速溶咖啡)中的他达拉非(TAD)和盐酸达泊西汀(DAP)。此外,还开发了一种创新的紫外分光光度法,能够用DAP分离药物二元混合物中的TAD。实现了一种新的计算方法来定制MT-MIP粒子的合成和设计。方法:采用一种新开发的基于傅立叶自去卷积(FSD)法和等吸收点的紫外分光光度法测定药物剂型中的TAD和DAP。使用开创性的绿色分析程序指数(GAPI)、包括样品制备在内的分析绿色性(AGREEprep)和AGREE工具,对SPE工艺和UV光谱方法的绿色性进行了评估。用扫描电子显微镜和能谱仪对合成的MT-MIP颗粒进行了表征。结果:建议的分光光度法显示出2-50的宽线性浓度范围 µg/mL,LOD较低,范围为0.604-0.994 µg/mL。此外,所提出的方法对其混合剂型和假冒食品中的目标表现出最大的敏感性和生态友好性。结论:SPE工艺和所开发的紫外光谱分析方法已根据ICH指南进行了验证,并被发现适用于监督商业蜂蜜和速溶咖啡壮阳产品中的一些假冒活动。亮点:成功开发了一种基于MT-MIP磁性聚合物的SPE方法和一种紫外光谱方法,用于分析不同基质中的TAD和DAP。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of AOAC International
Journal of AOAC International 医学-分析化学
CiteScore
3.10
自引率
12.50%
发文量
144
审稿时长
2.7 months
期刊介绍: The Journal of AOAC INTERNATIONAL publishes the latest in basic and applied research in analytical sciences related to foods, drugs, agriculture, the environment, and more. The Journal is the method researchers'' forum for exchanging information and keeping informed of new technology and techniques pertinent to regulatory agencies and regulated industries.
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