Therapeutic Applications of Plant and Nutraceutical-Based Compounds for the Management of Type 2 Diabetes Mellitus: A Narrative Review.

IF 2.4 Q3 ENDOCRINOLOGY & METABOLISM
Susha Dinesh, Sameer Sharma, Rajan Chourasiya
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引用次数: 0

Abstract

Diabetes mellitus is a condition caused by a deficiency in insulin production or sensitivity that is defined by persistent hyperglycemia as well as disturbances in glucose, lipid, and protein metabolism. Uncurbed diabetes or incessant hyperglycemic condition can lead to severe complications, including renal damage, visual impairment, cardiovascular disease, neuropathy, etc., which promotes diabetes-associated morbidity and mortality rates. The therapeutic management of diabetes includes conventional medications and nutraceuticals as complementary therapies. Nutraceuticals are bioactive compounds derived from food sources that have health-promoting properties and are instrumental in the management and treatment of various maladies. Nutraceuticals are clinically exploited to tackle DM pathogenesis, and the clinical evidence suggests that nutraceuticals can modulate biochemical parameters related to diabetes pathogenesis and comorbidities. Hypoglycemic medicines are designed to mitigate DM in traditional medicinal practice. This review intends to emphasize and comment on the various therapeutic strategies available to manage this chronic condition, conventional drugs, and the potential role of nutraceuticals in managing the complexity of the disease and reducing the risk of complications. In contrast to conventional antihyperglycemic drugs, nutraceutical supplements offer a higher efficacy and lesser adverse effects. To substantiate the efficacy and safety of various functional foods in conjunction with conventional hypoglycemic medicines, additional data from clinical studies are required.

植物和营养保健品化合物在治疗 2 型糖尿病中的应用:叙述性综述。
糖尿病是一种由于胰岛素分泌不足或敏感性降低引起的疾病,表现为持续性高血糖以及葡萄糖、脂质和蛋白质代谢紊乱。未得到控制的糖尿病或持续的高血糖可导致严重的并发症,包括肾损伤、视力损伤、心血管疾病、神经病变等,从而提高糖尿病相关疾病的发病率和死亡率。糖尿病的治疗管理包括传统药物和作为辅助疗法的营养保健品。营养保健品是从食物中提取的生物活性化合物,具有促进健康的特性,有助于控制和治疗各种疾病。临床上利用营养保健品来解决糖尿病的发病机理,临床证据表明,营养保健品可以调节与糖尿病发病机理和合并症有关的生化指标。在传统医学中,降糖药物旨在缓解糖尿病。本综述旨在强调和评论可用于控制这种慢性疾病的各种治疗策略、传统药物以及营养保健品在控制疾病复杂性和降低并发症风险方面的潜在作用。与传统的降糖药物相比,营养保健品的疗效更高,不良反应更少。要证实各种功能食品与传统降糖药物联用的疗效和安全性,还需要更多的临床研究数据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Current diabetes reviews
Current diabetes reviews ENDOCRINOLOGY & METABOLISM-
CiteScore
6.30
自引率
0.00%
发文量
158
期刊介绍: Current Diabetes Reviews publishes frontier reviews on all the latest advances on diabetes and its related areas e.g. pharmacology, pathogenesis, complications, epidemiology, clinical care, and therapy. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians who are involved in the field of diabetes.
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