Gastric Emptying Velocity After Labor Analgesia Assessed by Sonography: A Prospective Controlled Observational Study.

IF 2.3 3区医学 Q2 HEALTH CARE SCIENCES & SERVICES

Therapeutics and Clinical Risk Management Pub Date : 2023-01-01 DOI:10.2147/TCRM.S410984

Yongfeng Liu, Qian Wang, Qinghai Zuo

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引用次数: 0

Abstract

Objective: The effect of labor analgesia on gastric emptying rate will affect the management of fasting during the perinatal period. To evaluate gastric emptying after labor analgesia using the gastric antrum ultrasound examination.

Methods: From September 2022 to January 2023, a prospective controlled observational study was conducted. The Study group (epidural analgesia group) and Observation group (pharmacological and non-pharmacological interventions group) were successively enrolled and grouped using the random envelope method. However, labor analgesia was supplied according to maternal women's wishes, and intention-to-treat (ITT) and per-protocol (PP) analyses were performed to establish its effect on stomach emptying. The gastric emptying rate during the first stage of labor was considered to be the primary outcome.

Results: From September 2022 to January 2023, 120 persons were studied, 90 in the Study group and 30 in the Observation group. 33 people's analgesic selection was discordant with the grouped one. ITT analysis showed that the Study group's cross-sectional area (CSA) fell from baseline (624.19 ± 92.70 mm²) to 334.64 ± 46.32 mm² after 1 hour and to 217.26 ± 29.90 mm² after 2 hours. In the Observation group, the CSA similarly dropped from 620.10 ± 100.73 mm² to 331.30 ± 51.19 mm² and 214.70 ± 28.73 mm², p<0.001. CSA was not significantly different between groups, p>0.05. The PP analysis also indicated no significant changes in the CSA between the two groups at 3 time-points, p>0.05. At the first hour, the Study and Observation group had stomach emptying speeds of 300.05 ± 103.74 mm²/h and 259.50 ± 125.25 mm²/h, respectively, which were greater than those at the second hour (115.75 ± 43.51 mm²/h vs 124.36 ± 58.98 mm²/h), p<0.001.

Conclusion: Epidural analgesia, pharmacological, and non-pharmacological labor analgesia had little effect on gastric emptying, and gastric antrum ultrasonography can be utilized to monitor maternal gastric volume changes.

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超声评估分娩镇痛后胃排空速度:一项前瞻性对照观察研究。

目的:分娩镇痛对胃排空率的影响将影响围产期禁食的处理。目的:应用胃窦超声检查评价分娩镇痛后胃排空情况。方法:于2022年9月至2023年1月进行前瞻性对照观察研究。实验组(硬膜外镇痛组)和观察组(药物和非药物干预组)分别入组，采用随机包络法进行分组。然而，分娩镇痛是根据产妇的意愿提供的，并进行了意向治疗(ITT)和每个方案(PP)分析，以确定其对胃排空的影响。第一产程的胃排空率被认为是主要指标。结果:从2022年9月到2023年1月，120人被研究，其中研究组90人，观察组30人。33人的镇痛药选择与分组不一致。ITT分析显示，研究组的横截面积(CSA)从基线(624.19±92.70 mm2)下降到1小时后的334.64±46.32 mm2, 2小时后的217.26±29.90 mm2。观察组CSA由620.10±100.73 mm2降至331.30±51.19 mm2和214.70±28.73 mm2, pp>0.05。PP分析也显示两组在3个时间点的CSA无显著变化，p>0.05。研究组和观察组在分娩第1 h时胃排空速度分别为3000.05±103.74 mm2/h和259.50±125.25 mm2/h，均高于分娩第2 h时的排空速度(115.75±43.51 mm2/h vs 124.36±58.98 mm2/h)。结论:硬膜外镇痛、药物及非药物分娩镇痛对胃排空影响不大，胃窦超声可监测产妇胃容积变化。

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来源期刊

Therapeutics and Clinical Risk Management HEALTH CARE SCIENCES & SERVICES-

CiteScore

4.80

自引率

3.60%

发文量

139

审稿时长

16 weeks

期刊介绍： Therapeutics and Clinical Risk Management is an international, peer-reviewed journal of clinical therapeutics and risk management, focusing on concise rapid reporting of clinical studies in all therapeutic areas, outcomes, safety, and programs for the effective, safe, and sustained use of medicines, therapeutic and surgical interventions in all clinical areas. The journal welcomes submissions covering original research, clinical and epidemiological studies, reviews, guidelines, expert opinion and commentary. The journal will consider case reports but only if they make a valuable and original contribution to the literature. As of 18th March 2019, Therapeutics and Clinical Risk Management will no longer consider meta-analyses for publication. The journal does not accept study protocols, animal-based or cell line-based studies.