Efficacy and Safety of Introduction Timolol Maleate by Manometer Microneedles among Infantile Hemangioma: A Retrospective Study in China.

IF 1.5 3区医学 Q2 PEDIATRICS

European Journal of Pediatric Surgery Pub Date : 2024-06-01 Epub Date: 2023-05-01 DOI:10.1055/s-0043-57238

Lulu Yuan, Jia Wang

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Abstract

Objective: The objective of the study was to compare the effective rate, cure rate, adverse reaction rate, and effective time of three methods in the treatment of infantile hemangioma, hoping to provide reference for improving the clinical therapeutic effect.

Methods: This is a retrospective study of 307 infantile hemangioma patients admitted to the Department of Oral and Maxillofacial Surgery, School of Stomatology, China Medical University, from January 2014 to October 2021. The patients were divided into three groups. In group A, timolol maleate solution was introduced by the nano-microneedle technique (97 cases); in group B, timolol maleate drops dipped in medical swabs were applied (107 cases); and group C patients took propranolol orally (103 cases). The effective rate, cure rate, adverse reaction rate, and effective time of treatment were recorded and compared.

Results: The total effective rate, total cure rate, and total adverse reaction rate of the three groups were 87.6, 65.2, and 9.4%, respectively. The results showed that the effective and cure rates of group A were higher than those of group B (92.8 and 76.3%, respectively; p < 0.05), the adverse reaction rate of group C was higher than that of group B (17.5%, p < 0.05), and the effective time of group A was shorter than that of groups B and C. In most patients, symptoms significantly improved within 2 months (p < 0.05).

Conclusion: Timolol maleate introduced by nanometer microneedles is an effective and safe treatment for superficial hemangioma in infants with the highest effective and cure rates, lower incidence of adverse reactions, and the shortest effective treatment time.

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婴幼儿血管瘤患者使用马来酸噻吗洛尔微针导入的有效性和安全性：中国的一项回顾性研究

研究目的比较三种方法治疗婴幼儿血管瘤的有效率、治愈率、不良反应率、有效时间，为提高临床治疗效果提供参考：本研究以2014年1月-2021年10月中国医科大学口腔医学院口腔颌面外科收治的307例婴幼儿血管瘤患者为研究对象，进行回顾性研究。患者被分为三组。A组采用纳米微针技术导入马来酸噻吗洛尔溶液（97例）；B组采用医用棉签蘸取马来酸噻吗洛尔滴剂（107例）；C组患者口服普萘洛尔（103例）。记录并比较有效率、治愈率、不良反应率和治疗有效时间：结果：三组患者的总有效率、总治愈率和总不良反应率分别为 87.6%、65.2% 和 9.4%。结果显示，A 组的有效率和治愈率（分别为 92.8%和 76.3%）均高于 B 组（P P P P 结论：A 组的有效率和治愈率均高于 B 组（分别为 92.8%和 76.3%）：用纳米微针导入马来酸噻吗洛尔治疗婴儿浅表血管瘤是一种有效、安全的治疗方法，其有效率和治愈率最高，不良反应发生率较低，有效治疗时间最短。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pediatric Surgery 医学-外科

CiteScore

3.90

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： This broad-based international journal updates you on vital developments in pediatric surgery through original articles, abstracts of the literature, and meeting announcements. You will find state-of-the-art information on: abdominal and thoracic surgery neurosurgery urology gynecology oncology orthopaedics traumatology anesthesiology child pathology embryology morphology Written by surgeons, physicians, anesthesiologists, radiologists, and others involved in the surgical care of neonates, infants, and children, the EJPS is an indispensable resource for all specialists.