Increased Kremen2 predicts worse prognosis in colon cancer.

IF 2.3 4区医学 Q3 ONCOLOGY

Pathology & Oncology Research Pub Date : 2023-01-01 DOI:10.3389/pore.2023.1611082

Junxian Long, Fengyun Cong, Yousheng Wei, Jungang Liu, Weizhong Tang

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引用次数: 1

Abstract

Background: Colon cancer (CC) is the fifth most prevalent cancer around the globe and poses a major risk to human health. Even though Kremen2 serves as a prognostic indicator in individuals with malignant tumours, its role in evaluating the prognosis of individuals with colon cancer has not been confirmed. Methods: Here, we examined the protein expression of Kremen2 in CC tissues and paired adjacent normal tissues by immunohistochemistry (IHC), then analyzed the clinical and RNA-seq data presented in The Cancer Genome Atlas (TCGA) database to confirm the relationship between Kremen2 levels and CC. In addition, the associations between Kremen2 mRNA expression and infiltrating immune cells were examined. Results: The study showed that the mRNA expression and protein level of Kremen2 were increased in CC tissues compared with adjacent normal tissues. According to Kaplan-Meier analysis, high Kremen2 expression in CC was linked to poor overall survival and progression-free survival. Clinical correlation analysis highlighted that a high level of Kremen2 expression was strongly linked with tumour progression, particularly lymph node metastasis. Cox regression analysis highlighted that Kremen2 was an independent prognostic indicator for CC. Bioinformatic studies highlighted that Kremen2 might be associated with the immune status in CC. Conclusion: Increased Kremen2 could serve as a potential prognostic CC biomarker.

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clemen2升高预示结肠癌预后较差。

背景:结肠癌(CC)是全球第五大常见癌症，对人类健康构成重大风险。尽管Kremen2作为恶性肿瘤个体的预后指标，但其在评估结肠癌个体预后中的作用尚未得到证实。方法:采用免疫组化(immunohistochemistry, IHC)方法检测癌组织和配对的正常组织中Kremen2蛋白的表达，并分析美国癌症基因组图谱(the Cancer Genome Atlas, TCGA)数据库中的临床和RNA-seq数据，以证实Kremen2水平与癌之间的关系，同时检测其mRNA表达与浸润性免疫细胞之间的关系。结果:研究显示，与癌旁正常组织相比，癌旁组织中Kremen2 mRNA表达和蛋白水平均升高。根据Kaplan-Meier分析，在CC中，高表达的Kremen2与较差的总生存期和无进展生存期有关。临床相关分析强调，高水平的Kremen2表达与肿瘤进展，特别是淋巴结转移密切相关。Cox回归分析提示，Kremen2是一个独立的CC预后指标，生物信息学研究提示，Kremen2可能与CC的免疫状态有关，结论:增高的Kremen2可作为潜在的CC预后生物标志物。

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来源期刊

Pathology & Oncology Research 医学-病理学

CiteScore

6.30

自引率

0.00%

发文量

134

审稿时长

4-8 weeks

期刊介绍： Pathology & Oncology Research (POR) is an interdisciplinary Journal at the interface of pathology and oncology including the preclinical and translational research, diagnostics and therapy. Furthermore, POR is an international forum for the rapid communication of reviews, original research, critical and topical reports with excellence and novelty. Published quarterly, POR is dedicated to keeping scientists informed of developments on the selected biomedical fields bridging the gap between basic research and clinical medicine. It is a special aim for POR to promote pathological and oncological publishing activity of colleagues in the Central and East European region. The journal will be of interest to pathologists, and a broad range of experimental and clinical oncologists, and related experts. POR is supported by an acknowledged international advisory board and the Arányi Fundation for modern pathology.