Effects of sodium thiosulfate on serum calcification factors in patients undergoing maintenance hemodialysis.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2023-12-01 Epub Date: 2023-07-09 DOI:10.1111/1744-9987.14029

Pan Liu, Xiang Xu, YuFu Wang, XiaoNa Long, XunJia Li, HongYing Peng

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引用次数: 1

Abstract

Objective: To investigate the effect of sodium thiosulfate (STS) on serum calcification factors in patients undergoing maintenance hemodialysis.

Methods: Forty-four Patients were randomly divided into control group (n = 22) and observation group (n = 22) by envelope method (block 4 randomization). The control group received routine treatment while observation group was treated with STS on the basis of routine treatment. The biochemical indicators, including BUN, UA, SCr, Ca²⁺ , P^3- , calcium-phosphorus product, PTH, hs-CRP, TG, TC, HDL, LDL, and serum calcification factor MGP, FA, FGF-23, and OPG levels were compared before and after treatment.

Results: Control group had no statistically significant difference in the levels of vascular calcification factors MGP, FA, FGF-23, and OPG before and after treatment (p > 0.05). Whereas observation group had higher levels of MGP and FA, and lower levels of FGF-23 and OPG after treatment than before treatment (p < 0.05). The levels of MGP and FA in observation group were higher than those in control group, and FGF-23 and OPG were lower than those in control group (p < 0.05).

Conclusion: It is speculated that sodium thiosulfate can alleviate the progression of vascular calcification by changing the levels of calcification factors.

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硫代硫酸钠对维持性血液透析患者血清钙化因子的影响。

目的：探讨硫代硫酸钠（STS）对维持性血液透析患者血清钙化因子的影响。方法：将44例患者随机分为对照组（n = 22）和观察组（n = 22）（块4随机化）。对照组采用常规治疗，观察组在常规治疗的基础上采用STS治疗。比较治疗前后的生化指标，包括BUN、UA、SCr、Ca2+、P3-、钙磷产物、PTH、hs-CRP、TG、TC、HDL、LDL以及血清钙化因子MGP、FA、FGF-23和OPG水平。结果：对照组治疗前后血管钙化因子MGP、FA、FGF-23、OPG水平差异无统计学意义（p > 观察组治疗后MGP和FA水平高于治疗前，FGF-23和OPG水平低于治疗前（p 结论：硫代硫酸钠可以通过改变钙化因子的水平来减轻血管钙化的进展。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.