Roles of non-coding RNAs in intercellular crosstalk in cardiovascular diseases.

IF 1.6 4区医学 Q3 PHARMACOLOGY & PHARMACY

Korean Journal of Physiology & Pharmacology Pub Date : 2023-07-01 DOI:10.4196/kjpp.2023.27.4.289

Yeong-Hwan Lim, Young-Kook Kim

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Abstract

Complex diseases including cardiovascular disease are caused by a combination of the alternation of many genes and the influence of environments. Recently, non-coding RNAs (ncRNAs) have been shown to be involved in diverse diseases, and the functions of various ncRNAs have been reported. Many researchers have elucidated the mechanisms of action of these ncRNAs at the cellular level prior to in vivo and clinical studies of the diseases. Due to the characteristics of complex diseases involving intercellular crosstalk, it is important to study communication between multiple cells. However, there is a lack of literature summarizing and discussing studies of ncRNAs involved in intercellular crosstalk in cardiovascular diseases. Therefore, this review summarizes recent discoveries in the functional mechanisms of intercellular crosstalk involving ncRNAs, including microRNAs, long non-coding RNAs, and circular RNAs. In addition, the pathophysiological role of ncRNAs in this communication is extensively discussed in various cardiovascular diseases.

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非编码rna在心血管疾病细胞间串扰中的作用。

包括心血管疾病在内的复杂疾病是由许多基因的交替和环境的影响共同引起的。近年来，非编码rna (non-coding RNAs, ncRNAs)被证明参与多种疾病，各种ncRNAs的功能也被报道。在体内和临床研究之前，许多研究人员已经阐明了这些ncrna在细胞水平上的作用机制。由于涉及细胞间串扰的复杂疾病的特点，研究多细胞间的通讯具有重要意义。然而，缺乏文献综述和讨论ncrna在心血管疾病中参与细胞间串扰的研究。因此，本文综述了涉及ncRNAs(包括microRNAs、长链非编码rna和环状rna)的细胞间串扰功能机制的最新发现。此外，在各种心血管疾病中广泛讨论了ncrna在这种通讯中的病理生理作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Korean Journal of Physiology & Pharmacology PHARMACOLOGY & PHARMACY-PHYSIOLOGY

CiteScore

3.20

自引率

5.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Korean Journal of Physiology & Pharmacology (Korean J. Physiol. Pharmacol., KJPP) is the official journal of both the Korean Physiological Society (KPS) and the Korean Society of Pharmacology (KSP). The journal launched in 1997 and is published bi-monthly in English. KJPP publishes original, peer-reviewed, scientific research-based articles that report successful advances in physiology and pharmacology. KJPP welcomes the submission of all original research articles in the field of physiology and pharmacology, especially the new and innovative findings. The scope of researches includes the action mechanism, pharmacological effect, utilization, and interaction of chemicals with biological system as well as the development of new drug targets. Theoretical articles that use computational models for further understanding of the physiological or pharmacological processes are also welcomed. Investigative translational research articles on human disease with an emphasis on physiology or pharmacology are also invited. KJPP does not publish work on the actions of crude biological extracts of either unknown chemical composition (e.g. unpurified and unvalidated) or unknown concentration. Reviews are normally commissioned, but consideration will be given to unsolicited contributions. All papers accepted for publication in KJPP will appear simultaneously in the printed Journal and online.