Comparison of two ratios of xylazine:ketamine for the anesthesia of free-ranging North American beavers (Castor canadensis) in a remote setting.

IF 1.1 4区 农林科学 Q2 Veterinary
Stéphane Lair, Gregory Bourguelat, Gaétan Fournier
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引用次数: 0

Abstract

The objective of this study was to evaluate and compare 2 different xylazine:ketamine combination anesthetic protocols in free-ranging beavers (Castor canadensis). Twenty-two beavers (weighing 2.5 to 18.5 kg) were equally assigned to one of the following protocols: 1:10 xylazine:ketamine ratio and 3:10 xylazine:ketamine ratio. Using standard metabolic scaling, the following ranges of dosages were calculated and used: for the 1:10 xylazine:ketamine group 1.08 to 2.25 mg/kg (median = 1.2 mg/kg) of xylazine + 10.8 to 22.5 mg/kg (median = 12 mg/kg) of ketamine IM; andfor the 3:10 xylazine:ketamine group 2.04 to 3.67 mg/kg (median = 2.7 mg/kg) of xylazine + 6.81 to 12.25 mg/kg (median = 8.8 mg/kg) ketamine IM. Measured cardiorespiratory parameters and anesthetic event intervals were compared between protocols. Both protocols rapidly induced levels of anesthesia adequate for minimally invasive procedures of short duration. Durations of immobility ranged from 15 to 35 min and were not significantly different between the protocols (P = 0.64). Recovery phases, following the IM administration of 0.2 mg/kg of atipamezole 30 to 65 min post-induction, were usually faster with the 3:10 xylazine:ketamine protocol, but this was not statistically significant (P = 0.40). Heart rates were significantly lower with the 3:10 xylazine:ketamine protocol (P = 0.0002). PETCO2 values, measured with a nasal cannula, were similar between protocols and suggestive of hypoventilation. Despite the fact that the 3:10 xylazine:ketamine protocol was associated with a greater cardiac depression, the apparent, even if not statistically significant, faster recovery time with that protocol is definitively an asset for projects occurring in remote locations relying on helicopter transportation.

两种比例的氯胺酮对偏远地区自由放养的北美海狸(蓖麻)麻醉的比较。
本研究的目的是评估和比较两种不同的氯胺酮和氯胺酮联合麻醉方案在自由放养的海狸(蓖麻加拿大)。22只体重为2.5至18.5公斤的海狸被平均分配到以下方案之一:1:10的木嗪:氯胺酮比例和3:10的木嗪:氯胺酮比例。采用标准代谢标度法,计算并使用了以下剂量范围:1:10的木嗪:氯胺酮组:木嗪1.08 ~ 2.25 mg/kg(中位数= 1.2 mg/kg) +氯胺酮IM 10.8 ~ 22.5 mg/kg(中位数= 12 mg/kg);对于3:10的木嗪:氯胺酮组为2.04 ~ 3.67 mg/kg(中位数= 2.7 mg/kg)的木嗪+ 6.81 ~ 12.25 mg/kg(中位数= 8.8 mg/kg)的氯胺酮IM。比较两种方案测量的心肺参数和麻醉事件间隔。两种方案都能迅速诱导麻醉水平,足以满足短时间微创手术的需要。固定时间从15到35分钟不等,两种方案之间无显著差异(P = 0.64)。诱导后30 ~ 65 min,给予0.2 mg/kg阿替帕唑IM后的恢复阶段,通常以3:10的噻嗪:氯胺酮方案更快,但这没有统计学意义(P = 0.40)。3:10噻嗪:氯胺酮方案的心率显著降低(P = 0.0002)。使用鼻套管测量的PETCO2值在两种方案之间相似,提示通气不足。尽管3:10的噻嗪:氯胺酮方案与更大的心脏抑制有关,但显然,即使没有统计上的显著性,该方案更快的恢复时间对于依赖直升机运输的偏远地区的项目来说绝对是一项资产。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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