Dysregulation of metalloproteinases in spinal ligament degeneration.

IF 2.8 4区医学 Q3 CELL BIOLOGY

Connective Tissue Research Pub Date : 2023-07-01 DOI:10.1080/03008207.2022.2160327

Chao Wang, Ziran Wei, Tengbo Yu, Lu Zhang

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引用次数: 0

Abstract

Purpose: Degenerative changes in the spinal ligaments, such as hypertrophy or ossification, are important pathophysiological mechanisms of secondary spinal stenosis and neurological compression. Extracellular matrix (ECM) remodeling is one of the major pathological changes in ligament degeneration, and in this remodeling, ECM proteinase-mediated degradation of elastin and collagen plays a vital role. Zinc-dependent endopeptidases, including matrix metalloproteinases (MMPs), a disintegrin and metalloproteinases (ADAMs), and ADAMs with thrombospondin-1 motifs (ADAMTSs) are key factors in ECM remodeling. This review aims to elucidate the underlying mechanisms of these metalloproteinases in the initiation and progression of spinal ligament degeneration.

Methods: We clarify current literature on the dysregulation of MMPs/ADAMs/ADAMTS and their endogenous inhibitors in degenerative spinal ligament diseases. In addition, some instructive information was excavated from the raw data of the relevant high-throughput analysis.

Results and conclusions: The dysregulation of metalloproteinases and their endogenous inhibitors may affect ligament degeneration by involving several interrelated processes, represented by ECM degradation, fibroblast proliferation, and osteogenic differentiation. Antagonists of the key targets of the processes may in turn ease ligament degeneration.

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金属蛋白酶在脊柱韧带变性中的失调。

目的:脊柱韧带的退行性改变，如肥大或骨化，是继发性椎管狭窄和神经压迫的重要病理生理机制。细胞外基质(Extracellular matrix, ECM)重构是韧带退行性变的主要病理变化之一，而在这种重构中，ECM蛋白酶介导的弹性蛋白和胶原蛋白降解起着至关重要的作用。锌依赖的内肽酶，包括基质金属蛋白酶(MMPs)、崩解素和金属蛋白酶(ADAMs)以及带有血栓反应蛋白-1基序的ADAMs (ADAMTSs)是ECM重塑的关键因素。本文旨在阐明这些金属蛋白酶在脊髓韧带变性的发生和发展中的潜在机制。方法:我们对目前关于退行性脊髓韧带疾病中MMPs/ADAMs/ADAMTS及其内源性抑制剂失调的文献进行了澄清。此外，从相关高通量分析的原始数据中挖掘出一些有指导意义的信息。结果和结论:金属蛋白酶及其内源性抑制剂的失调可能涉及几个相互关联的过程，如ECM降解、成纤维细胞增殖和成骨分化，从而影响韧带变性。这些过程关键靶点的拮抗剂可能反过来缓解韧带退变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Connective Tissue Research 生物-细胞生物学

CiteScore

6.60

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： The aim of Connective Tissue Research is to present original and significant research in all basic areas of connective tissue and matrix biology. The journal also provides topical reviews and, on occasion, the proceedings of conferences in areas of special interest at which original work is presented. The journal supports an interdisciplinary approach; we present a variety of perspectives from different disciplines, including Biochemistry Cell and Molecular Biology Immunology Structural Biology Biophysics Biomechanics Regenerative Medicine The interests of the Editorial Board are to understand, mechanistically, the structure-function relationships in connective tissue extracellular matrix, and its associated cells, through interpretation of sophisticated experimentation using state-of-the-art technologies that include molecular genetics, imaging, immunology, biomechanics and tissue engineering.