Heart failure associated with ustekinumab therapy for treatment of Crohn's Disease.

Q4 Medicine
Drug and Therapeutics Bulletin Pub Date : 2023-11-01 Epub Date: 2023-06-30 DOI:10.1136/dtb.2023.250376rep
Erica Morgenweck, Brian Park, Richard Bower
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引用次数: 0

Abstract

A man in his 60s with penetrating ileocolonic Crohn’s disease (CD), recently started on ustekinumab therapy, presented with new onset dyspnoea, paroxysmal nocturnal dyspnoea and dependent oedema. He was diagnosed with heart failure (HF) 10 months after starting ustekinumab therapy. His symptoms resolved with discontinuation of ustekinumab and he had recovery of his cardiac function. Though initial studies that led to the U.S Food and Drug Administration (FDA)approval for ustekinumab did not detect a signal for HF, postmarketing surveillance has detected rare cases of HF after initiation of the medication. This is one of the few reported cases of HF associated with ustekinumab therapy for CD.
与ustekinumab治疗克罗恩病相关的心力衰竭。
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来源期刊
Drug and Therapeutics Bulletin
Drug and Therapeutics Bulletin Medicine-Pharmacology (medical)
CiteScore
0.80
自引率
0.00%
发文量
69
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