A novel device and system concept for therapeutic plasma exchange in rats.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2023-08-01 DOI:10.1111/1744-9987.13989

Mitică Ciorpac, Cezar-Cătălin Caratașu, Andrei Szilagyi, Cosmin-Teodor Mihai, Ionut Nistor, Radu Iliescu, Bogdan Ionel Tamba

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引用次数: 0

Abstract

Introduction: Therapeutic plasma exchange (TPE) has been developed more than 100 years ago in an animal model and adapted to humans 30 years later. Since then, the TPE research on animal models is lacking, mainly due to difficulties raised by the scaling of the plasmapheresis unit so that the animal's cardiovascular parameters are not considerably affected.

Methods: The system concept of a novel TPE device with continuous hemodynamic monitoring in small rodent models has been used.

Results: A continuum TPE unit for rats has been developed, able to produce up to 95% plasma exchange rate without any TPE-related hemodynamic impairment, monitored up to 35 days after the procedure.

Conclusion: The TPE unit for rats was able to produce 95% plasma exchange rate in non-anesthetized animals, enabling a full translation of the human TPE into an animal model. The newly developed plasmapheresis unit enable a wide range of more accurate preclinical evaluation, with cardiac parameters monitoring, using small rodents in awaken state.

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一种用于大鼠治疗性血浆交换的新装置和系统概念。

治疗性血浆交换(TPE)早在100多年前就在动物模型中发展起来，30年后才适用于人类。此后，TPE在动物模型上的研究缺乏，主要是由于血浆分离装置的缩放带来了困难，因此动物的心血管参数没有受到很大影响。方法:采用一种新型TPE装置的系统概念，在小型啮齿动物模型上进行连续血流动力学监测。结果:一种连续的大鼠TPE装置已经开发出来，能够产生高达95%的血浆交换率，而没有任何TPE相关的血流动力学损伤，在手术后监测长达35天。结论:大鼠TPE单元在非麻醉动物中能够产生95%的血浆交换率，实现了人类TPE完全转化为动物模型。新开发的血浆分离装置可以在唤醒状态下使用小啮齿动物进行心脏参数监测，从而实现更广泛、更准确的临床前评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.