Effect of Ramadan fasting on chronic inflammation markers and gut bacterial endotoxins among Egyptian hemodialysis patients.

IF 1.5 4区医学 Q3 HEMATOLOGY

Therapeutic Apheresis and Dialysis Pub Date : 2023-08-01 DOI:10.1111/1744-9987.13988

Emad Samaan, Ahmed A Eldeeb, Ahmed B Ibrahim, Mohammed Erman, Alaa A Sabry, Mostafa A Mahmoud

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引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) is associated with a state of chronic inflammation. This study aimed to investigate effects of Ramadan fasting on the markers of chronic inflammation and gut bacterial endotoxin levels in maintenance hemodialysis.

Method: A prospective self-controlled observational study included 45 patients. Serum levels of High Sensitive CRP (hsCRP), indoxyl sulfate, and trimethylamine-n-levels were measured within a week before and a week after Ramadan fasting.

Results: Twenty-seven patients have fasted more than 15 days (29 ± 2.2 days). The levels of high sensitive C-reactive protein (hsCRP) (median of 62 mg/L vs. 91 mg/L), trimethylamine-n-oxide (TMAO) (median of 4.5 μmoL/L vs. 17 μmoL/L), platelet-to-lymphocyte ratio (PLR) (mean of 98.9 mg/L vs. 111.8 mg/L) and neutrophil-to-lymphocyte ratio (NLR) (median of 1.56 vs. 1.59) were significantly lower after Ramadan fasting with p < 0.001, p < 0.001, p < 0.001, and p = 0.04, respectively.

Conclusion: A beneficial effect of Ramadan fasting on levels of bacterial endotoxins and markers of chronic inflammation in hemodialysis patients was observed.

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斋月禁食对埃及血液透析患者慢性炎症标志物和肠道细菌内毒素的影响。

背景:慢性肾脏疾病(CKD)与慢性炎症状态相关。本研究旨在探讨斋月禁食对维持性血液透析患者慢性炎症标志物和肠道细菌内毒素水平的影响。方法:采用前瞻性自我对照观察性研究，纳入45例患者。在斋月禁食前一周和禁食后一周内测定血清中高敏CRP (hsCRP)、硫酸吲哚酚和三甲胺n水平。结果:27例患者禁食超过15天(29±2.2天)。斋月禁食后，高敏感c反应蛋白(hsCRP)水平(中位数为62 mg/L vs. 91 mg/L)、三甲胺-氧化三甲胺(TMAO)水平(中位数为4.5 μmoL/L vs. 17 μmoL/L)、血小板-淋巴细胞比率(PLR)水平(平均为98.9 mg/L vs. 111.8 mg/L)和中性粒细胞-淋巴细胞比率(NLR)水平(中位数为1.56 vs. 1.59)均显著降低，p < 0.05。观察到斋月禁食对血液透析患者细菌内毒素水平和慢性炎症标志物的有益影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Therapeutic Apheresis and Dialysis 医学-泌尿学与肾脏学

CiteScore

3.00

自引率

10.50%

发文量

166

审稿时长

6-12 weeks

期刊介绍： Therapeutic Apheresis and Dialysis is the official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis and the Japanese Society for Dialysis Therapy. The Journal publishes original articles, editorial comments, review articles, case reports, meeting abstracts and Communications information on apheresis and dialysis technologies and treatments.