{"title":"Effect of Bedding Substrates on Blood Glucose and Body Weight in Mice.","authors":"Sylvia Y Kondo, Jasmine Kropik, Michael Adly Wong","doi":"10.30802/AALAS-JAALAS-22-000047","DOIUrl":null,"url":null,"abstract":"<p><p>Differences in cage microenvironments may contribute to variation in data and affect the outcome of animal studies involving metabolic diseases. To study this, we compared the effects 3 types of bedding-corncob bedding, hardwood bedding, and hardwood bedding plus a cardboard enrichment item-on baseline fasting and nonfasting blood glucose and body weight in mice. Mice housed on corncob bedding showed significantly higher fasting blood glucose than did mice housed on hardwood bedding, with or without the enrichment item. None of the groups showed an effect of bedding type on nonfasting blood glucose levels or body weight. This information informs the choice of bedding substrates for studies that measure fasting blood glucose and potentially mitigates a variable that could confound research outcomes.</p>","PeriodicalId":50019,"journal":{"name":"Journal of the American Association for Laboratory Animal Science","volume":null,"pages":null},"PeriodicalIF":1.2000,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9732771/pdf/jaalas2022000611.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of the American Association for Laboratory Animal Science","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.30802/AALAS-JAALAS-22-000047","RegionNum":3,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Differences in cage microenvironments may contribute to variation in data and affect the outcome of animal studies involving metabolic diseases. To study this, we compared the effects 3 types of bedding-corncob bedding, hardwood bedding, and hardwood bedding plus a cardboard enrichment item-on baseline fasting and nonfasting blood glucose and body weight in mice. Mice housed on corncob bedding showed significantly higher fasting blood glucose than did mice housed on hardwood bedding, with or without the enrichment item. None of the groups showed an effect of bedding type on nonfasting blood glucose levels or body weight. This information informs the choice of bedding substrates for studies that measure fasting blood glucose and potentially mitigates a variable that could confound research outcomes.
期刊介绍：
The Journal of the American Association for Laboratory Animal Science (JAALAS) serves as an official communication vehicle for the American Association for Laboratory Animal Science (AALAS). The journal includes a section of refereed articles and a section of AALAS association news.
All signed articles, including refereed articles and book reviews, editorials, committee reports, and news and commentary, reflect the individual views of the authors and are not official views of AALAS. The mission of the refereed section of the journal is to disseminate high-quality, peer-reviewed information on animal biology, technology, facility operations, management, and compliance as relevant to the AALAS membership. JAALAS accepts research reports (data-based) or scholarly reports (literature-based), with the caveat that all articles, including solicited manuscripts, must include appropriate references and must undergo peer review.
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