Correlation between E-cadherin expression and tumor grade, proliferation, microvascular density, and apoptosis in canine cutaneous squamous cell carcinoma.

IF 1.1 4区 农林科学 Q2 Veterinary
Ashish Gupta, Ahmad Al-Dissi
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引用次数: 0

Abstract

E-cadherin is an adhesion molecule expressed on epithelial surfaces. Loss of its expression is described in cancerous tissues. Here, we examined the expression of E-cadherin in canine cutaneous squamous cell carcinoma (SCC) and determined its association with tumor grade (TG), proliferation index (PI), apoptosis index (AI), and intra-tumoral microvascular density (iMVD) in archived samples. Thirty-six cutaneous SCC samples (archived from 2014 to 2019) were graded and E-cadherin level, Ki67 (PI), von Willebrand factor (iMVD), and apoptosis (AI) were determined immunohistochemically. Tumor grades were assigned as Grade 1 (n = 18), Grade 2 (n = 16), and Grade 3 (n = 2). Of the 36 tumors, 21 were digital and 15 were from other locations, including the tail, neck, ear, and elbow. The median E-cadherin score decreased statistically (P = 0.03) with an increase in TG. There was a negative association between median E-cadherin score and TG (r = -0.445, P = 0.013), AI (r = -0.342, P = 0.08), and PI (r = -0.459, P = 0.016). The median E-cadherin score was significantly higher in digital SCC compared to SCC from other locations (P = 0.035). In conclusion, a negative association was observed between TG, PI, AI, and E-cadherin.

犬皮肤鳞状细胞癌中E-cadherin表达与肿瘤分级、增殖、微血管密度和细胞凋亡的关系。
e -钙粘蛋白是一种表达于上皮表面的粘附分子。它的表达缺失是在癌组织中描述的。在这里,我们检测了E-cadherin在犬皮肤鳞状细胞癌(SCC)中的表达,并确定了其与存档样本中肿瘤分级(TG)、增殖指数(PI)、凋亡指数(AI)和肿瘤内微血管密度(iMVD)的关系。对2014 - 2019年36例皮肤SCC样本进行分级,免疫组织化学检测E-cadherin水平、Ki67 (PI)、von Willebrand因子(iMVD)和凋亡(AI)。肿瘤分级为1级(n = 18)、2级(n = 16)和3级(n = 2)。在36例肿瘤中,21例为指端肿瘤,15例为其他部位肿瘤,包括尾部、颈部、耳朵和肘部。E-cadherin评分中位数随TG升高而降低,差异有统计学意义(P = 0.03)。E-cadherin中位评分与TG (r = -0.445, P = 0.013)、AI (r = -0.342, P = 0.08)、PI (r = -0.459, P = 0.016)呈负相关。与其他部位的SCC相比,数字SCC的E-cadherin评分中位数明显更高(P = 0.035)。综上所述,TG、PI、AI与E-cadherin呈负相关。
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来源期刊
CiteScore
1.80
自引率
0.00%
发文量
58
审稿时长
>24 weeks
期刊介绍: The Canadian Journal of Veterinary Research, published by the Canadian Veterinary Medical Association, is Canada''s only veterinary research publication. This quarterly peer-reviewed online-only journal has earned a wide international readership through the publishing of high quality scientific papers in the field of veterinary medicine. The Journal publishes the results of original research in veterinary and comparative medicine.
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