Clinical characteristics and prognosis of Korean patients with hepatocellular carcinoma with respect to etiology.

Wonjoon Jang, Hye Won Lee, Jae Seung Lee, Beom Kyung Kim, Seung Up Kim, Jun Yong Park, Sang Hoon Ahn, Do Young Kim
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引用次数: 5

Abstract

Background/aim: The profile of patients with hepatocellular carcinoma (HCC) has changed globally; the role of etiology in predicting prognosis of HCC patients remains unclear. We aimed to analyze the characteristics and prognosis of Korean patients with HCC according to disease etiology.

Methods: This retrospective observational study included patients diagnosed with HCC between 2010 and 2014 in a single center in Korea. Patients with HCC aged <19 years old, had coinfection with other viral hepatitis, had missing follow-up data, were Barcelona Clinic Liver Cancer stage D, or died before 1 month were excluded.

Results: A total of 1,595 patients with HCC were analyzed; they were classified into the hepatitis B virus (HBV) group (1,183 [74.2%]), hepatitis C virus (HCV) group (146 [9.2%]), and non-B non-C (NBNC) group (266 [16.7%]). The median overall survival of all patients was 74 months. The survival rates at 1, 3, and 5 years were 78.8%, 62.0% and 54.9% in the HBV group; 86.0%, 64.0%, and 48.6% in the HCV group; and 78.4%, 56.5%, and 45.9% in the NBNC group, respectively. NBNC-HCC has a poorer prognosis than other causes of HCC. Survival was significantly longer in the HBV group with early-stage HCC than in the NBNC group. Furthermore, survival was shorter in patients with early-stage HCC and diabetes mellitus (DM) than in those without DM.

Conclusions: The etiology of HCC affected clinical characteristics and prognosis to some extent. NBNC-HCC patients showed shorter overall survival than viral-related HCC patients. Additionally, the presence of DM is an additional important prognostic factor in patients with early-stage HCC.

Abstract Image

Abstract Image

韩国肝细胞癌患者的临床特点及病因预后分析。
背景/目的:肝细胞癌(HCC)患者的概况在全球范围内发生了变化;病因学在预测HCC患者预后中的作用尚不清楚。我们的目的是根据疾病的病因分析韩国HCC患者的特点和预后。方法:这项回顾性观察性研究纳入了2010年至2014年在韩国单一中心诊断为HCC的患者。结果:共分析1595例HCC患者;分为乙型肝炎病毒(HBV)组(1183例[74.2%])、丙型肝炎病毒(HCV)组(146例[9.2%])和非乙型非丙型肝炎(NBNC)组(266例[16.7%])。所有患者的中位总生存期为74个月。HBV组1、3、5年生存率分别为78.8%、62.0%和54.9%;HCV组分别为86.0%、64.0%和48.6%;NBNC组分别为78.4%、56.5%和45.9%。NBNC-HCC的预后比其他原因的HCC差。HBV组合并早期HCC患者的生存期明显长于NBNC组。早期HCC合并糖尿病(DM)患者的生存期短于无DM患者。结论:HCC的病因在一定程度上影响其临床特征和预后。NBNC-HCC患者的总生存期短于病毒相关HCC患者。此外,糖尿病的存在是早期HCC患者另一个重要的预后因素。
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