Kidney Lymphatics.

IF 4.2 2区 医学 Q1 PHYSIOLOGY
Peter S Russell, Max Itkin, John A Windsor, Anthony R J Phillips
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引用次数: 1

Abstract

Following significant advances in lymphatic biology, the important role of kidney lymphatics in kidney function and dysfunction is now being more fully appreciated. Kidney lymphatics begin in the cortex as blind-ended lymphatic capillaries and then coalesce into larger lymphatics that follow the main blood vessels out through the kidney hilum. Their function in draining interstitial fluid, macromolecules, and cells underpins their important role in kidney fluid and immune homeostasis. This article provides a comprehensive overview of recent and more established research findings on kidney lymphatics and the implications of these findings for kidney function and disease. The use of lymphatic molecular markers has greatly expanded our knowledge of the development, anatomy, and pathophysiology of kidney lymphatics. Significant recent discoveries include the diverse embryological source of kidney lymphatics, the hybrid nature of the ascending vasa recta, and the effects of lymphangiogenesis on kidney diseases such as acute kidney injury and renal fibrosis. On the basis of these recent advances, there is now an opportunity to link information from across multiple research disciplines to drive a new era of lymphatic-targeted therapies for kidney disease. © 2023 American Physiological Society. Compr Physiol 13:4945-4984, 2023.

肾淋巴管。
随着淋巴生物学的重大进展,肾淋巴在肾脏功能和功能障碍中的重要作用现在得到了更充分的认识。肾淋巴管开始于皮质,作为盲端淋巴毛细血管,然后合并成更大的淋巴管,跟随主血管穿过肾门。它们在引流间质液、大分子和细胞方面的功能支撑了它们在肾液和免疫稳态中的重要作用。这篇文章提供了一个全面的概述最近和更成熟的研究发现肾淋巴和这些发现对肾功能和疾病的影响。淋巴分子标记的使用极大地扩展了我们对肾淋巴的发育、解剖和病理生理学的认识。最近的重大发现包括肾淋巴的不同胚胎学来源,上升直血管的杂交性质,以及淋巴管生成对肾脏疾病(如急性肾损伤和肾纤维化)的影响。在这些最新进展的基础上,现在有机会将来自多个研究学科的信息联系起来,以推动肾脏疾病淋巴靶向治疗的新时代。©2023美国生理学会。[j] .物理学报(英文版),2009(3):444 - 444。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
10.50
自引率
0.00%
发文量
38
审稿时长
6-12 weeks
期刊介绍: Comprehensive Physiology is the most authoritative and comprehensive collection of physiology information ever assembled, and uses the most powerful features of review journals and electronic reference works to cover the latest key developments in the field, through the most authoritative articles on the subjects covered. This makes Comprehensive Physiology a valued reference work on the evolving science of physiology for both researchers and clinicians. It also provides a useful teaching tool for instructors and an informative resource for medical students and other students in the life and health sciences.
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