Preoperative albumin-alkaline phosphatase ratio affects the prognosis of patients undergoing hepatocellular carcinoma surgery.

IF 2.2 4区医学 Q3 ONCOLOGY

Cancer Biomarkers Pub Date : 2024-01-01 DOI:10.3233/CBM-230108

Wei Huang, Suosu Wei, Xiaofeng Dong, Yuntian Tang, Yi Tang, Hongjun Liu, Junzhang Huang, Jianrong Yang

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引用次数: 0

Abstract

Background: The correlation between the preoperative albuminalkaline phosphatase ratio (AAPR) and the prognosis of hepatocellular carcinoma (HCC) patients after radical resection is still not comprehensive.

Objective: This study aims to observe the correlation between preoperative AAPR and the prognosis of HCC patients after radical resection.

Methods: We constructed a retrospective cohort study and included 656 HCC patients who underwent radical resection. The patients were grouped after determining an optimum AAPR cut-off value. We used the Cox proportional regression model to assess the correlation between preoperative AAPR and the prognosis of HCC patients after radical resection.

Results: The optimal cut-off value of AAPR for assessing the prognosis of HCC patients after radical resection was 0.52 which was acquired by using X-tile software. Kaplan-Meier analysis curves showed that a low AAPR (⩽ 0.52) had a significantly lower rate of overall survival (OS) and recurrence-free survival (RFS) (P< 0.05). Multiple Cox proportional regression showed that an AAPR > 0.52 was a protective factor for OS (HR = 0.66, 95%CI 0.45-0.97, p= 0.036) and RFS (HR = 0.70, 95% CI 0.53-0.92, p= 0.011).

Conclusions: The preoperative AAPR level was related to the prognosis of HCC patients after radical resection and can be used as a routine preoperative test, which is important for early detection of high-risk patients and taking personalized adjuvant treatment.

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术前白蛋白-碱性磷酸酶比值会影响肝细胞癌手术患者的预后。

背景：术前白蛋白-碱性磷酸酶比值（AAPR）与肝细胞癌（HCC）根治性切除术后预后的相关性仍不全面：本研究旨在观察术前白蛋白与碱性磷酸酶比值（AAPR）与根治性切除术后肝细胞癌（HCC）患者预后的相关性：我们构建了一项回顾性队列研究，纳入了 656 例接受根治性切除术的 HCC 患者。在确定最佳 AAPR 临界值后对患者进行分组。我们使用 Cox 比例回归模型评估了术前 AAPR 与根治性切除术后 HCC 患者预后之间的相关性：结果：使用 X-tile 软件得出评估根治性切除术后 HCC 患者预后的最佳 AAPR 临界值为 0.52。Kaplan-Meier 分析曲线显示，低 AAPR（⩽ 0.52）患者的总生存率（OS）和无复发生存率（RFS）明显较低（P< 0.05）。多重考克斯比例回归显示，AAPR>0.52是OS（HR=0.66，95%CI 0.45-0.97，P= 0.036）和RFS（HR=0.70，95%CI 0.53-0.92，P= 0.011）的保护因素：术前AAPR水平与根治性切除术后HCC患者的预后有关，可作为术前常规检测项目，这对早期发现高危患者并采取个性化辅助治疗非常重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Biomarkers ONCOLOGY-

CiteScore

5.20

自引率

3.20%

发文量

195

审稿时长

3 months

期刊介绍： Concentrating on molecular biomarkers in cancer research, Cancer Biomarkers publishes original research findings (and reviews solicited by the editor) on the subject of the identification of markers associated with the disease processes whether or not they are an integral part of the pathological lesion. The disease markers may include, but are not limited to, genomic, epigenomic, proteomics, cellular and morphologic, and genetic factors predisposing to the disease or indicating the occurrence of the disease. Manuscripts on these factors or biomarkers, either in altered forms, abnormal concentrations or with abnormal tissue distribution leading to disease causation will be accepted.