Epidemiological, clinical, and prognostic analysis of oral squamous cell carcinoma diagnosed and treated in a single hospital in Galicia (Spain): a retrospective study with 5-year follow-up.

IF 2.2 3区医学

Medicina oral, patologia oral y cirugia bucal Pub Date : 2024-01-01 DOI:10.4317/medoral.26047

I Amezaga-Fernandez, J-M Aguirre-Urizar, J-M Suárez-Peñaranda, C Chamorro-Petronacci, I Lafuente-Ibáñez de Mendoza, X Marichalar-Mendia, A Blanco-Carrión, J Antúnez-López, A García-García

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引用次数: 0

Abstract

Background: Oral cancer is a common neoplasm worldwide, mostly corresponding to squamous cell carcinoma (OSCC). Unfortunately, its overall prognosis remains poor, with no improvement in recent decades. In this study, we have analysed the epidemiological, clinical, and prognostic characteristics of OSCC on patients of a specific Spanish region (Galicia), in order to improve its prognosis and apply effective preventive and early diagnosis measures.

Material and methods: We retrospectively analysed 243 cases of OSCC, diagnosed and treated in a single hospital centre in Galicia between 2010 and 2015 (minimum of 5 years of evolution). Overall and specific survival were calculated (Kaplan-Meier) and associated variables were identified (log rank test and Cox regression).

Results: The mean age of the patients was 67 years, with the majority being male (69.5%), smokers (45.9%) and alcohol consumers (58.6%), who lived in non-urban areas (79.4%). Cases diagnosed at advanced stages entailed the 48.1% of the sample, and 38.7% of cases relapsed. The 5-year overall and disease-specific survival rates were 39.9% and 46.1%, respectively. Patients who consumed tobacco and alcohol had a worse prognosis. OSCC cases referred to hospital by specialist dentists had a better prognosis, as those who were previously diagnosed with an oral potentially malignant oral disorder (OPMD) or received dental care during OSCC treatment.

Conclusions: In view of these findings, we conclude that OSCC in Galicia (Spain) still has a very poor overall prognosis, which is mainly related to the advanced age of the patients and the late diagnosis. Our study highlights the better survival of OSCC in relation to the referring health professional, the presence of a previous OPMD and the dental care after diagnosis. This demonstrates the importance of dentistry as a health profession involved in the early diagnosis and multidisciplinary management of this malignant neoplasm.

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加利西亚（西班牙）一家医院诊断和治疗的口腔鳞状细胞癌的流行病学、临床和预后分析：一项为期 5 年的回顾性研究。

背景：口腔癌是全球常见的肿瘤，主要是鳞状细胞癌（OSCC）。不幸的是，其总体预后仍然很差，近几十年来没有任何改善。在这项研究中，我们分析了西班牙一个特定地区（加利西亚）OSCC 患者的流行病学、临床和预后特征，以改善其预后并采取有效的预防和早期诊断措施：我们回顾性分析了 2010 年至 2015 年期间在加利西亚一家医院中心诊断和治疗的 243 例 OSCC 病例（病程至少 5 年）。我们计算了总生存率和特定生存率（卡普兰-梅耶尔），并确定了相关变量（对数秩检验和考克斯回归）：患者的平均年龄为 67 岁，大多数为男性（69.5%）、吸烟者（45.9%）和饮酒者（58.6%），居住在非城市地区（79.4%）。在样本中，48.1%的病例诊断为晚期，38.7%的病例复发。5年总生存率和疾病特异性生存率分别为39.9%和46.1%。吸烟和饮酒的患者预后较差。由专科牙医转诊到医院的OSCC病例预后较好，因为那些曾被诊断为口腔潜在恶性口腔疾病（OPMD）或在OSCC治疗期间接受过牙科治疗的患者预后较好：鉴于这些发现，我们得出结论：加利西亚（西班牙）的OSCC总体预后仍然很差，这主要与患者年龄偏大和诊断较晚有关。我们的研究强调，OSCC 较好的存活率与转诊医疗专业人员、既往是否患有 OPMD 以及诊断后的牙科护理有关。这表明牙科作为一种医疗专业，在这种恶性肿瘤的早期诊断和多学科治疗中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina oral, patologia oral y cirugia bucal Medicine-Surgery

CiteScore

4.50

自引率

0.00%

发文量

期刊介绍： 1. Oral Medicine and Pathology: Clinicopathological as well as medical or surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, as well as orofacial neurological disorders, and systemic conditions with an impact on the oral cavity. 2. Oral Surgery: Surgical management aspects of diseases affecting oral mucosa, salivary glands, maxillary bones, teeth, implants, oral surgical procedures. Surgical management of diseases affecting head and neck areas. 3. Medically compromised patients in Dentistry: Articles discussing medical problems in Odontology will also be included, with a special focus on the clinico-odontological management of medically compromised patients, and considerations regarding high-risk or disabled patients. 4. Implantology 5. Periodontology