Are Measles-Mumps-Rubella (MMR) Antibodies Friends or Foes for Covid-19 Disease?

IF 2.9 4区 医学 Q3 IMMUNOLOGY
Azza Salamony, Yara Shamikh, Khaled Amer, Tarek Elnagdy, Mostafa Elnakib, Abd Allah Yehia, Wael Hassan, Maha Abdelsalam
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引用次数: 0

Abstract

Many factors have been implicated in the pathogenesis and severity of COVID-19 pandemic. A wide variation in the susceptibility for SARS-CoV-2 infection among different population, gender and age has been observed. Multiple studies investigated the relationship between the antibody’s titre of previously vaccinated individuals and the susceptibility of coronavirus infection, to find a rapid effective therapy for this pandemic. This study focused on the association between measles-mumps-rubella (MMR) antibodies titre and the severity of COVID-19 infection. We aimed to investigate the correlation between the antibody’s titre of MMR and the SARS-CoV-2 infection susceptibility and disease severity, in a cohort of COVID-19 Egyptian patients, compared to a control group. MMR antibody titre was measured using enzyme Linked Immune Sorbent Assay; (ELISA) for 136 COVID-19 patients and 44 healthy individuals, as control group. There were high levels of measles and mumps antibodies titer in the deteriorating cases, which could not protect from SARS-CoV-2 infection. However, the rubella antibodies might protect from SARS-CoV-2 infection, but once the infection occurs, it may aggravate the risk of case deterioration. MMR antibodies could be used as a guideline for COVID-19 symptom-severity and, in turn, may be considered as an economic prognostic marker used for early protection from multiple autoimmune organ failure.

麻疹-腮腺炎-风疹(MMR)抗体对Covid-19疾病是友还是敌?
COVID-19大流行的发病机制和严重程度涉及许多因素。观察到不同人群、性别和年龄对SARS-CoV-2感染的易感性存在很大差异。多项研究调查了以前接种过疫苗的个体的抗体滴度与冠状病毒感染易感性之间的关系,以找到一种快速有效的治疗方法。这项研究的重点是麻疹-腮腺炎-风疹(MMR)抗体滴度与COVID-19感染严重程度之间的关系。我们的目的是在COVID-19埃及患者队列中,与对照组相比,研究MMR抗体滴度与SARS-CoV-2感染易感性和疾病严重程度之间的相关性。采用酶联免疫吸附法测定MMR抗体滴度;(ELISA)检测136例COVID-19患者和44例健康人作为对照组。在病情恶化的病例中,麻疹和腮腺炎抗体滴度较高,不能保护患者免受SARS-CoV-2感染。然而,风疹抗体可能对SARS-CoV-2感染有保护作用,但一旦感染,可能会加剧病例恶化的风险。MMR抗体可作为COVID-19症状严重程度的指南,反过来,可被视为一种经济的预后标志物,用于早期保护多种自身免疫器官衰竭。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.90
自引率
0.00%
发文量
26
审稿时长
>12 weeks
期刊介绍: Archivum Immunologiae et Therapiae Experimentalis (AITE), founded in 1953 by Ludwik Hirszfeld, is a bimonthly, multidisciplinary journal. It publishes reviews and full original papers dealing with immunology, experimental therapy, immunogenetics, transplantation, microbiology, immunochemistry and ethics in science.
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