Exercise Therapy in Early Multiple Sclerosis Improves Physical Function But Not Cognition: Secondary Analyses From a Randomized Controlled Trial.

IF 3.7 2区医学 Q1 CLINICAL NEUROLOGY

Neurorehabilitation and Neural Repair Pub Date : 2023-05-01 DOI:10.1177/15459683231159659

Morten Riemenschneider, Lars G Hvid, Thor Petersen, Egon Stenager, Ulrik Dalgas

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引用次数: 1

Abstract

Background: Exercise positively affects multiple sclerosis (MS) symptoms, physiological systems, and potentially cognition. However, an uninvestigated "window of opportunity" exists for exercise therapy early in the disease.

Objective: This study presents secondary analyses from the Early Multiple Sclerosis Exercise Study, and aims to investigate the efficacy of exercise on physical function, cognition, and patient-reported measures of disease and fatigue impact early in the disease course of MS.

Methods: This randomized controlled trial (n = 84, time since diagnosis <2 years) included 48 weeks of aerobic exercise or an active control condition (health education) and between-group changes are based on repeated measurement mixed regression models. Physical function tests included measures of aerobic fitness, walking (6-minute walk, Timed 25-foot walk, Six-spot step test), and upper-limb dexterity. Tests of processing speed and memory evaluated cognition. The questionnaires Multiple Sclerosis Impact Scale and Modified Fatigue Impact Scale assessed perception of disease and fatigue impact.

Results: Following early exercise aerobic fitness showed superior between-group physiological adaptations (4.0 [1.7; 6.3] ml O₂/min/kg; large effect size [ES = 0.90]). No other outcomes showed significant between-group differences, yet all measures of walking and upper-limb function showed small-to-medium effect sizes in favor of exercise (ES = 0.19-0.58). Overall disability status as well as cognition were unaffected by exercise, whereas perception of disease and fatigue impact were reduced in both groups.

Conclusion: In early MS, 48 weeks of supervised aerobic exercise seem to positively modify physical function, but not cognitive function. Perception of disease and fatigue impact may be modifiable by exercise in early MS.

Trial registration: Clinicaltrials.gov (identifier: NCT03322761).

查看原文本刊更多论文

早期多发性硬化症的运动治疗改善了身体功能，但没有改善认知:来自随机对照试验的二次分析。

背景:运动对多发性硬化症(MS)症状、生理系统和潜在的认知有积极影响。然而，在疾病早期运动治疗存在一个未经调查的“机会之窗”。目的:本研究对早期多发性硬化症运动研究进行了二次分析，旨在探讨运动对ms病程早期身体功能、认知和患者报告的疾病和疲劳影响的影响。方法:本随机对照试验(n = 84，自诊断以来)结果:早期运动后有氧适能表现出更好的组间生理适应(4.0 [1.7;6.3] ml O2/min/kg;大效应量[ES = 0.90])。没有其他结果显示组间有显著差异，但所有的步行和上肢功能测量都显示了有利于运动的中小型效应量(ES = 0.19-0.58)。整体残疾状况和认知不受运动影响，而两组的疾病感知和疲劳影响都有所减少。结论:在早期MS中，48周的有氧运动似乎对身体功能有积极的影响，但对认知功能没有积极的影响。早期多发性硬化患者的疾病感知和疲劳影响可以通过锻炼来改变。试验注册:Clinicaltrials.gov(标识符:NCT03322761)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurorehabilitation and Neural Repair 医学-康复医学

CiteScore

8.30

自引率

4.80%

发文量

审稿时长

6-12 weeks

期刊介绍： Neurorehabilitation & Neural Repair (NNR) offers innovative and reliable reports relevant to functional recovery from neural injury and long term neurologic care. The journal''s unique focus is evidence-based basic and clinical practice and research. NNR deals with the management and fundamental mechanisms of functional recovery from conditions such as stroke, multiple sclerosis, Alzheimer''s disease, brain and spinal cord injuries, and peripheral nerve injuries.