Emotional dysregulation, alexithymia and neuroticism: a systematic review on the genetic basis of a subset of psychological traits.

IF 1.5 4区医学 Q4 GENETICS & HEREDITY

Psychiatric Genetics Pub Date : 2023-06-01 Epub Date: 2022-12-20 DOI:10.1097/YPG.0000000000000335

Giovanni Castellini, Giuseppe Pierpaolo Merola, Ottone Baccaredda Boy, Vincenzo Pecoraro, Bernardo Bozza, Emanuele Cassioli, Eleonora Rossi, Valentina Bessi, Sandro Sorbi, Benedetta Nacmias, Valdo Ricca

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引用次数: 0

Abstract

Neuroticism, alexithymia and emotion dysregulation are key traits and known risk factors for several psychiatric conditions. In this systematic review, the aim is to evaluate the genetic contribution to these psychological phenotypes. A systematic review of articles found in PubMed was conducted. Search terms included 'genetic', 'GWAS', 'neuroticism', 'alexithymia' and 'emotion dysregulation'. Risk of bias was assessed utilizing the STREGA checklist. Two hundred two papers were selected from existing literature based on the inclusion and exclusion criteria. Among these, 27 were genome-wide studies and 175 were genetic association studies. Single gene association studies focused on selected groups of genes, mostly involved in neurotransmission, with conflicting results. GWAS studies on neuroticism, on the other hand, found several relevant and replicated intergenic and intronic loci affecting the expression and regulation of crucial and well-known genes (such as DRD2 and CRHR1). Mutations in genes coding for trascriptional factors were also found to be associated with neuroticism (DCC, XKR6, TCF4, RBFOX1), as well as a noncoding regulatory RNA (LINC00461). On the other hand, little GWAS data are available on alexythima and emotional dysregulation.

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情绪失调、述情障碍和神经质：一项关于心理特征子集遗传基础的系统综述。

神经质、述情障碍和情绪失调是几种精神疾病的关键特征和已知的危险因素。在这篇系统综述中，目的是评估遗传对这些心理表型的贡献。对PubMed上的文章进行了系统综述。搜索词包括“遗传”、“GWAS”、“神经质”、“述情障碍”和“情绪失调”。使用STREGA检查表评估偏倚风险。根据纳入和排除标准，从现有文献中选择了222篇论文。其中，27项是全基因组研究，175项是遗传关联研究。单基因关联研究集中在选定的基因组上，这些基因大多与神经传递有关，但结果相互矛盾。另一方面，GWAS对神经质的研究发现，几个相关和复制的基因间和内含子基因座影响关键和已知基因（如DRD2和CRHR1）的表达和调节。编码转录因子的基因突变也被发现与神经质（DCC、XKR6、TCF4、RBFOX1）以及非编码调节RNA（LINC00461）有关。另一方面，GWAS关于alexythima和情绪失调的数据很少。

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来源期刊

Psychiatric Genetics 医学-神经科学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： The journal aims to publish papers which bring together clinical observations, psychological and behavioural abnormalities and genetic data. All papers are fully refereed. Psychiatric Genetics is also a forum for reporting new approaches to genetic research in psychiatry and neurology utilizing novel techniques or methodologies. Psychiatric Genetics publishes original Research Reports dealing with inherited factors involved in psychiatric and neurological disorders. This encompasses gene localization and chromosome markers, changes in neuronal gene expression related to psychiatric disease, linkage genetics analyses, family, twin and adoption studies, and genetically based animal models of neuropsychiatric disease. The journal covers areas such as molecular neurobiology and molecular genetics relevant to mental illness. Reviews of the literature and Commentaries in areas of current interest will be considered for publication. Reviews and Commentaries in areas outside psychiatric genetics, but of interest and importance to Psychiatric Genetics, will also be considered. Psychiatric Genetics also publishes Book Reviews, Brief Reports and Conference Reports.