Promises and challenges of cardiac organoids.

IF 2.7 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Mammalian Genome Pub Date : 2023-06-01 Epub Date: 2023-04-04 DOI:10.1007/s00335-023-09987-y

Jingxian Li, Jingsi Yang, Dandan Zhao, Wei Lei, Shijun Hu

引用次数: 1

Abstract

Cardiovascular diseases are currently the main cause of death. The study of the pathogenesis and treatment of these diseases is still a major challenge. Traditional 2D cultured cells and animal models have certain limitations. Heart organoids as models can simulate the structure and function of the body, providing a new research strategy. This paper mainly discusses the development of organoids and their application in the study of the cardiac developmental process, drug screening and treatment of genetic and non-genetic diseases, concluding with their strengths and weaknesses.

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心脏类器官的前景和挑战。

心血管疾病目前是导致死亡的主要原因。对这些疾病的发病机制和治疗的研究仍然是一个重大挑战。传统的二维培养细胞和动物模型存在一定的局限性。以心脏类器官为模型可以模拟人体的结构和功能，为心脏类器官的研究提供了新的思路。本文主要讨论了类器官的发展及其在心脏发育过程研究、遗传和非遗传性疾病的药物筛选和治疗等方面的应用，并总结了它们的优缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mammalian Genome 生物-生化与分子生物学

CiteScore

4.00

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Mammalian Genome focuses on the experimental, theoretical and technical aspects of genetics, genomics, epigenetics and systems biology in mouse, human and other mammalian species, with an emphasis on the relationship between genotype and phenotype, elucidation of biological and disease pathways as well as experimental aspects of interventions, therapeutics, and precision medicine. The journal aims to publish high quality original papers that present novel findings in all areas of mammalian genetic research as well as review articles on areas of topical interest. The journal will also feature commentaries and editorials to inform readers of breakthrough discoveries as well as issues of research standards, policies and ethics.