Pablo Thomas Dupont, Irma Yadira Izaguirre-Hernández, José María Remes-Troche
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引用次数: 0
Abstract
Irritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder defined by disturbances in bowel habits and abdominal pain, in the absence of known organic pathology that affects between 5 to 10% of healthy populations. Despite improvements in detection and treatment, the pathogenesis of IBS has not been clarified. Several microRNAs (miRNAs) are involved in the pathogenesis of IBS through increased intestinal permeability, inflammation, and modulation of visceral hyperalgesia, and they may have the potential to be used as biomarkers and therapeutic targets. Here, we have summarized the recent advances about the role of miRNAs in the development of IBS symptoms and the possibility to use them as therapeutic targets to mitigate symptoms in IBS.
期刊介绍：
The Journal of Gastrointestinal and Liver Diseases (formerly Romanian Journal of Gastroenterology) publishes papers reporting original clinical and scientific research, which are of a high standard and which contribute to the advancement of knowledge in the field of gastroenterology and hepatology. The field comprises prevention, diagnosis and management of gastrointestinal and hepatobiliary disorders, as well as related molecular genetics, pathophysiology, and epidemiology. The journal also publishes reviews, editorials and short communications on those specific topics. Case reports will be accepted if of great interest and well investigated.
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