Preliminary Study on the Association of Serum Branched-Chain Amino Acids With Lipid and Hepatic Markers.

IF 1.4 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Cardiology Research Pub Date : 2023-06-01 DOI:10.14740/cr1454

Hari Krishnan Krishnamurthy, Swarnkumar Reddy, Vasanth Jayaraman, Karthik Krishna, Qi Song, Tianhao Wang, Kang Bei, John J Rajasekaran

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引用次数: 1

Abstract

Background: Serum levels of branched-chain amino acids (BCAAs) are associated with various vital physiological functions and thus elevation in circulating levels results in several metabolic disturbances. Serum levels of BCAAs are strong predictors of various metabolic disorders. Their association with cardiovascular health is uncertain. The study aimed to investigate the association of BCAAs with circulating levels of vital cardiovascular and hepatic markers.

Methods: The study population of 714 individuals was included from the population tested for the vital cardio and hepatic biomarkers at the Vibrant America Clinical Laboratories. The subjects were stratified into four quartiles based on the serum levels of BCAAs, and their association with vital markers was studied using the Kruskal-Wallis test. Pearson's correlation analyzed the univariant relationship of BCAAs with selected cardio and hepatic markers.

Results: BCAAs exhibited a strong negative correlation with serum HDL. Serum triglycerides were found to have a positive correlation with serum levels of leucine and valine. Univariant analysis exhibited a strong negative correlation between serum levels of BCAAs and HDL, and a positive correlation was observed between triglycerides and amino acids isoleucine and leucine. Among analyzed hepatic markers, alanine transaminase exhibited a considerable association with BCAAs.

Conclusions: The elevated levels of serum BCAAs are strongly associated with serum HDL and triglycerides. Consumption of these supplements must be in coordination with healthcare providers to avoid metabolic and cardiovascular risk.

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血清支链氨基酸与脂质和肝脏标志物相关性的初步研究。

背景:支链氨基酸(BCAAs)的血清水平与多种重要生理功能有关，因此循环水平升高会导致多种代谢紊乱。血清支链氨基酸水平是各种代谢紊乱的有力预测指标。它们与心血管健康的关系尚不确定。该研究旨在探讨支链氨基酸与重要心血管和肝脏标志物循环水平的关系。方法:研究人群为714人，这些人来自于在美国临床实验室进行重要心脏和肝脏生物标志物检测的人群。根据血清BCAAs水平将受试者分为四个四分之一，并使用Kruskal-Wallis测试研究其与生命标志物的相关性。Pearson相关性分析了BCAAs与选定的心脏和肝脏标志物的单变量关系。结果:支链氨基酸与血清HDL呈显著负相关。血清甘油三酯与血清亮氨酸和缬氨酸水平呈正相关。单变量分析显示血清BCAAs水平与HDL呈显著负相关，甘油三酯水平与氨基酸异亮氨酸和亮氨酸呈正相关。在分析的肝脏标志物中，丙氨酸转氨酶显示出与支链氨基酸相当大的关联。结论:血清BCAAs水平升高与血清HDL和甘油三酯密切相关。这些补充剂的使用必须与医疗保健提供者协调，以避免代谢和心血管风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cardiology Research CARDIAC & CARDIOVASCULAR SYSTEMS-

CiteScore

2.50

自引率

0.00%

发文量

期刊介绍： Cardiology Research is an open access, peer-reviewed, international journal. All submissions relating to basic research and clinical practice of cardiology and cardiovascular medicine are in this journal''s scope. This journal focuses on publishing original research and observations in all cardiovascular medicine aspects. Manuscript types include original article, review, case report, short communication, book review, letter to the editor.