Voluntary wheel running promotes resilience to the behavioral effects of unpredictable chronic mild stress in male and female mice.

IF 2.6 4区 心理学 Q2 BEHAVIORAL SCIENCES
Elias Elias, Ariel Y Zhang, Abigail G White, Matthew J Pyle, Melissa T Manners
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引用次数: 1

Abstract

Besides significant benefits to physical health, exercise promotes mental health, reduces symptoms of mental illness, and enhances psychological development. Exercise can offset the impact of chronic stress, which is a major precursor to the development of mental disorders. The effects of exercise on chronic stress-induced behaviors are contradictory in preclinical studies, primarily due to the lack of data and sex-specific investigations. We sought to evaluate the effects of exercise on chronic stress-induced behavioral changes in both male and female mice. Mice were subjected to an Unpredictable Chronic Mild Stress (UCMS) paradigm with accessibility to running wheels for 2 h daily. Physiological and behavioral evaluations were conducted throughout the stress paradigm to determine if exercise blunts the effects of UCMS. Chronic stress induced voluntary wheel running (VWR) and weight loss in male and female mice. Compared to males, increased VWR was reported in females who also regained their weight lost by the end of the UCMS protocol. Exercise promoted resilience to stress-induced hyponeophagia in the novelty-suppressed feeding test and increased sucrose consumption. Exercise induced a sex-specific reduction in immobility and avoidance behavior in the tail suspension and open field tests and increased exploratory behavior in the light-dark test. These results indicate that exercise can promote resilience to the behavioral effects of chronic stress in males and females, and can affect behavior independent of chronic stress.

在雄性和雌性小鼠中,自愿跑轮促进了对不可预测的慢性轻度压力的行为影响的恢复能力。
除了对身体健康有显著的好处外,锻炼还能促进心理健康,减少心理疾病的症状,促进心理发展。运动可以抵消慢性压力的影响,而慢性压力是精神障碍发展的主要前兆。在临床前研究中,运动对慢性压力诱发行为的影响是相互矛盾的,主要是由于缺乏数据和性别特异性调查。我们试图评估运动对雄性和雌性小鼠慢性应激性行为改变的影响。小鼠受到不可预测的慢性轻度应激(UCMS)范式,每天可进入跑步轮2小时。在整个应激范式中进行了生理和行为评估,以确定运动是否会减弱UCMS的效果。慢性应激诱导雄性和雌性小鼠自主轮跑(VWR)和体重减轻。与男性相比,据报道,在UCMS方案结束时体重恢复的女性的VWR增加。在新奇性抑制进食测试中,运动促进了应激性低食性的恢复能力,并增加了蔗糖的消耗。在尾巴悬挂和开阔场地测试中,运动诱导了性别特异性的静止和回避行为的减少,在光暗测试中增加了探索行为。这些结果表明,运动可以促进男性和女性对慢性应激行为影响的恢复力,并且可以影响独立于慢性应激的行为。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
5.60
自引率
0.00%
发文量
25
审稿时长
6-12 weeks
期刊介绍: The journal Stress aims to provide scientists involved in stress research with the possibility of reading a more integrated view of the field. Peer reviewed papers, invited reviews and short communications will deal with interdisciplinary aspects of stress in terms of: the mechanisms of stressful stimulation, including within and between individuals; the physiological and behavioural responses to stress, and their regulation, in both the short and long term; adaptive mechanisms, coping strategies and the pathological consequences of stress. Stress will publish the latest developments in physiology, neurobiology, molecular biology, genetics research, immunology, and behavioural studies as they impact on the understanding of stress and its adverse consequences and their amelioration. Specific approaches may include transgenic/knockout animals, developmental/programming studies, electrophysiology, histochemistry, neurochemistry, neuropharmacology, neuroanatomy, neuroimaging, endocrinology, autonomic physiology, immunology, chronic pain, ethological and other behavioural studies and clinical measures.
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