Example of use of clock time-dependent targets for patient-based quality control.

IF 2.1 4区医学 Q3 MEDICAL LABORATORY TECHNOLOGY

Annals of Clinical Biochemistry Pub Date : 2024-01-01 Epub Date: 2023-06-22 DOI:10.1177/00045632231185472

Douglas F Stickle

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引用次数: 0

Abstract

Background: Running means for total calcium (Ca) results at our laboratory exhibit a stable time-of-day (TOD) periodic pattern. We examined use of TOD-dependent targets for running means in patient-based quality control (PBQC) for Ca.

Methods: Primary data were Ca results over a 3 month interval, restricted to weekday data within the Ca reference interval (8.5-10.3 mg/dL; 2.12-2.57 mmol/L). Running means were evaluated as sliding averages of 20 samples (20-mers).

Results: Data comprised 39,629 consecutive Ca measurements (75.3% inpatient (IP)) for which Ca was 9.29±0.47 mg/dL. The all data average for 20-mers was 9.29 ± 0.18 mg/dL. When parsed in 1 h TOD intervals, however, averages among 20-mers ranged from 9.1 to 9.5 mg/dL, with blocs of contiguous results above (0800-2300 h; 53.3% of results; IP = 75.3%) and below (2300-0800 h; 46.7% of results; IP = 99.9%) the all-data mean. There was thus an inherent TOD-dependent pattern of deviation of means from target when using a fixed PBQC target. Using Fourier series analysis as an example approach, characterization of the pattern to produce TOD-dependent PBQC targets eliminated this inherent inaccuracy.

Conclusions: In circumstances of periodic variation in running means, simple characterization of that variation can reduce the probability of both false positive and false negative flags in PBQC.

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使用时钟时间相关目标进行患者质量控制的实例。

背景：我们实验室的总钙（Ca）结果均值运行呈现稳定的时间-日期（TOD）周期模式。我们研究了在以患者为基础的钙质量控制（PBQC）中使用依赖于 TOD 的均值运行目标的情况：主要数据是 3 个月内的 Ca 结果，仅限于 Ca 参考区间（8.5-10.3 mg/dL；2.12-2.57 mmol/L）内的工作日数据。运行平均值以 20 个样本（20 个聚合物）的滑动平均值进行评估：数据包括 39,629 次连续 Ca 测量（75.3% 为住院病人 (IP)），其中 Ca 为 9.29±0.47 mg/dL。所有数据中 20-mers 的平均值为 9.29 ± 0.18 mg/dL。然而，当按 1 小时 TOD 间隔进行分析时，20-mers 的平均值介于 9.1 至 9.5 mg/dL 之间，连续结果群高于（8:00-23:00；53.3% 的结果；IP = 75.3%）和低于（23:00-08:00；46.7% 的结果；IP = 99.9%）所有数据的平均值。因此，在使用固定的 PBQC 目标时，平均值偏离目标的情况与 TOD 有关。使用傅立叶序列分析作为示例方法，对产生与 TOD 有关的 PBQC 目标的模式进行描述，消除了这种固有的不准确性：结论：在运行平均值周期性变化的情况下，对这种变化进行简单的特征描述可以降低 PBQC 中出现假阳性和假阴性标志的概率。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Clinical Biochemistry Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

5.20

自引率

4.50%

发文量

期刊介绍： Annals of Clinical Biochemistry is the fully peer reviewed international journal of the Association for Clinical Biochemistry and Laboratory Medicine. Annals of Clinical Biochemistry accepts papers that contribute to knowledge in all fields of laboratory medicine, especially those pertaining to the understanding, diagnosis and treatment of human disease. It publishes papers on clinical biochemistry, clinical audit, metabolic medicine, immunology, genetics, biotechnology, haematology, microbiology, computing and management where they have both biochemical and clinical relevance. Papers describing evaluation or implementation of commercial reagent kits or the performance of new analysers require substantial original information. Unless of exceptional interest and novelty, studies dealing with the redox status in various diseases are not generally considered within the journal''s scope. Studies documenting the association of single nucleotide polymorphisms (SNPs) with particular phenotypes will not normally be considered, given the greater strength of genome wide association studies (GWAS). Research undertaken in non-human animals will not be considered for publication in the Annals. Annals of Clinical Biochemistry is also the official journal of NVKC (de Nederlandse Vereniging voor Klinische Chemie) and JSCC (Japan Society of Clinical Chemistry).